Protein
DNA-binding protein Ewg
Organism
Drosophila melanogaster
Function
May function as a positive regulator of transcription in developing and differentiated neurons, regulating common aspects of neuronal differentiation and maintenance. Requirement in the CNS may be higher than in the peripheral system. Vital for development of the indirect flight muscles.
Similarity
Belongs to the NRF1/Ewg family.
Sequence
MATTSYRLVVAPAGSQRSSTGNVVVTTTSSGSHSSNGANGGTGGTSAGSSTLGSGLNVTTITATSGGQLQSAGNTSQSNGTTYKIEMLEEDIQSLGSDDDDEDLISSDGSLYEGDLGSMPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPTIHTVTTMTPPTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAQNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVSAAQAHAHSQSQAHSQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQGYPVSVSNVISVPVSMYQSVMANVQQIQTNSDGTVCLAPMQVENGDQLETITMSPGMHQMMIQGGPGQEPQLVQVVSLKDATLLSKAMEAINSGNVKSEDTIIMEQ