Organism
Caenorhabditis elegans
Function
Acts as a receptor for slt-1 (PubMed:17901337). Required for the guidance of the AVM pioneer axon to the ventral nerve cord (PubMed:17901337). Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline (PubMed:25122090).
Similarity
Belongs to the EVA1 family.
Sequence
MNMHIVSPVLLLFWFGIIVTDGKLKSGFIGGSHHHEVNPIEGILRESLRSNRVQACDGERITLSCPRNTQISVQTGFYGRVVPENQLCPPQAGRKHSEANLDPLSMIHHSSTCDVIQAHTRISELCDKRRKCTVVVDSNTFEDDPCPTTSKYLQMAYGCIPMSFDEETFCTPKPTDPPRPEIRLECREGRRLAVYSAQMKTSPQCDPETEIRHECVSDVLPQVLRQCHAKEGCTLKSDGIKGHCRHGHLHVVYVCVNEEIFSEEAIKGELTSLETYLKEADAMQKQDDERFFKDVNDKTQWERVVDSEPAKDPDVHQIANDASYVTHDEYRMEKQDPPPITERVEPNLVGVGHDLLQVVQFFKENKEKAVMCIVLAVSMAAIVVLSACIITRLCSSNKDSSRSSRRSRSRRSLETSKLVSSNYGGSITPQHMMQDIEDEQFLRFSMGSAATSNPHYSHYDF