Protein
S-adenosylmethionine synthase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Similarity
Belongs to the AdoMet synthase family.
Sequence
MATNGVNGAKHYNEGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAKLDYQKVVRNAIKDIGYDDSSKGFDYKTCNLLVAIEEQSPDIAQGLHLDDRLENLGAGDQGIMFGYATDETPELFPLTLLFAHKLNAAMSAARRDGSLPWLRPDTKTQVTIEYKHDNGAVVPLRVDTVVVSAQHAPEITTEELRKEILEKIIKTTIPAKYLDEKTVYHIQPSGLFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSLVAAGLARRALVQLSYAIGVAEPLSIYVDTYGTSDKTSEELVQIIRNNFDLRPGVIVKELDLAKPIYLQTAKNGHFGTNQSFSWEKPKALKF