Protein
ESAT-6-like protein EsxO
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function
Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacillary persistence. Increases host oxidative stress response, leading to genomic instability and decrease in macrophage viability. Also induces autophagy and modulates the immune function of macrophages.
Similarity
Belongs to the WXG100 family. ESAT-6 subfamily.
Sequence
MTINYQFGDVDAHGAMIRAQAGLLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA