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ero-1

Gene
ero-1
Protein
Endoplasmic reticulum oxidoreductin-1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
668 amino acids
Function
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
Similarity
Belongs to the EROs family.
Mass
75.607 kDa
Sequence
MKPASRLFYLSLFALWSPEAQCKSDESCAISPKAIVSDACASYSTLEQLNRDIKPALEDLTRTTDFFSHYRLNLFNKECPFWNDENGMCGNIACAVETLDNEEDIPEVWRAKELGKLEGPRAKHPGKSVQKEEPKRPLQGKLGEDVGESCVVEYDDECDDRDYCVPDDEGASSKGDYVSLLRNPERFTGYAGDGAKQVWDAIYRENCFQKSSFPKSASLGDTYSVPKNPAAQDFRAVMQAAGRQHMLEQQREQNPLVPFVTKTGLESEDECLEKRVFYKIVSGMHASISTHLCWDFLNQTTGQWQPNLSCYINRLHKFPERISNLYFNYALLTRAVAKLGPYLSSHEEYTFCTGDPAQDADTRAKVLAVTSKAANTVPGPVFDESIMFKNGEGPSLKEDFRNRFRNISRLMDCVGCDKCRLWGKLQTAGYGTALKVLFEFANNDTSATSSETDEIPFKLKRTELVALFNTYARLSSSLDAIQKFRAMVEESEEGQQPQSHEQIEGSENSGAHHIPDRAKKPRHVIVPTPDAADHAEASDTNTATTAVDEAKAAGVTPAPKVEHQQQVEVDNNDDDDDDDEFHEFQRQPQQPDTDPNFVYKKRTLKDDFENEFRAVFAAFKLVIRSYLNLPALIYEITITELKRFWQFYVGLPVMPRTWEFRRPSLDEL

Gene
ero-1
Protein
Endoplasmic reticulum oxidoreductin-1
Organism
Caenorhabditis elegans
Length
478 amino acids
Function
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).
Similarity
Belongs to the EROs family.
Mass
55.154 kDa
Sequence
MREPLLQLIVLSLIIIVVNTQFESGRLCFCKGFEAVEPCDCSKPQTIDKLNNHRIYEKVQKLLKKDFFRFYKVNMDKTCPFWADDRQCGTNQCGIAFCDDEVPAGLRRRNAVNMEAAAVKEEEDDDAEKCADAGNNIDPMDRTLHDDEKRQLDAMDHHDDGLEDKFCEIEDDESDGMHYVDLSKNPERYTGYAGKSPQRVWKSIYEENCFKPDPKFDKNFLTNPSNFGMCLEKRVFYRLISGLHSAITISIAAYNYKPPPPSLGQFGSQMGTWFRNTEMFAGRFGTKWSWEGPQRLRNVYFIYLLELRALLKAAPYLQNELFYTGNDVEDAETRKAVEDLLEEIRAYPNHFDESEMFTGVESHARALREEFRSHFVNISRIMDCVECDKCRLWGKVQTHGMGTALKILFSDLPHSHYKQDSSKFQLTRNEVVALLQSFGRYSSSILEVDNFREDMYPGESVMNTAADGPPRKSNKIDL