About Products Protein Database Contact

erlin1

Gene
ERLIN1
Protein
Erlin-1
Organism
Homo sapiens
Length
348 amino acids
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).
Similarity
Belongs to the band 7/mec-2 family.
Mass
39.171 kDa
Sequence
MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG
Protein
Erlin-1: ERLIN1

Gene
Erlin1
Protein
Erlin-1
Organism
Mus musculus
Length
348 amino acids
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).
Similarity
Belongs to the band 7/mec-2 family.
Mass
39.182 kDa
Sequence
MNMTQARLLVAAVVGLVAILLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNTMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKRAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPSMFVDSSCALKYSDGRTGREDSLPPEEAREPSGESPIQNKENAG
Protein
Erlin-1: Erlin1

Gene
ERLIN1
Protein
Erlin-1
Organism
Pongo abelii
Length
348 amino acids
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity).
Similarity
Belongs to the band 7/mec-2 family.
Mass
39.209 kDa
Sequence
MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSHPSKEALEPSGENLIQNKESTG
Protein
Erlin-1: ERLIN1

Gene
erlin1
Protein
Erlin-1
Organism
Danio rerio
Length
342 amino acids
Function
Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
Similarity
Belongs to the band 7/mec-2 family.
Mass
38.319 kDa
Sequence
MAHVGAVVAAMAGLMAILLHSSIHKIEEGHLAVYYRGGALLTSPNGPGYHIMLPFITSYRSVQTTLQTDEIKNVPCGTSGGVMIYFDRIEVVNMLIPTSVVDIVRNYTADYDKTLIFNKIHHELNQFCSVHTLQEVYIELFDIIDENLKTALQKDLNCMAPGLTIQAVRVTKPKIPEAIRRNYELMEAEKTRLLITVQTQKVVEKEAETERKKAIIEAQKVAQVAEIQFQQKVMEKETEKKISEIEDAAFLAREKARADAEYYTAAKFAEANTLKLTPEYLQLMKYQAIAANSKIYFGQDIPNMFVDSSASRPAAGESEQLESLSMRESLKKASKPKASEGH
Protein
Erlin-1: erlin1

Gene
erlin1
Protein
Erlin-1
Organism
Xenopus tropicalis
Length
319 amino acids
Function
Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
Similarity
Belongs to the band 7/mec-2 family.
Mass
36.311 kDa
Sequence
MAHFGVVVGLMMILVFLVFLSSIHKVEEGHLAVYYRGGALLGGPGDPGYHIMFPFITYFRSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNMLTPSAVYDVVRNYTADYDKTLIFNKIHHELNQFCSSHTLQEVYIELFDQIDENLKLSLQMELNVMAPGLTIQAVRVTKPKIPEAIRRNFELMESEKTKLLIAEQRQKVVEKEAETERKKAVIEAEKVAQVAKIQYRQKVMEKETEKFISEIEDSAYLAREKAKADAEYYTAQKSADANKLKLTPQYLELIKYQAVSANNKIYFGSNIPTMFFDSSSRSRIEGKSA
Protein
Erlin-1: erlin1