Protein
Delta(14)-sterol reductase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.
Similarity
Belongs to the ERG4/ERG24 family.
Sequence
MAGKQNQAAPKKAVAPRQQHYEFGGPIGAFGITFGLPILVHVFNLFCNDISGCPAPSLLHPKSLDLAQLKREIGWPDNGVFGLFSWSATLWTLGYYALSLVQYRFLPGHHVEGTELSTGGRLKYKLNAFNSAMCTLAILAAGTIAQGAEFPVWTFISDNFAQIISANILFAFALAIFVYVRSFDVKPGNKDMRQLAAGGVTGSLIYDFYIGRELNPRITLPLIGQVDIKEFMEMRPGLLGWIILNCAFIAKQYRLYGYVTDSILFITAIQAFYVFDGIYMEPAVLTTMDITTDGFGFMLSFGDVVWVPFMYSTQTRYLSVHPQQLGAFGLIAVGAVLAAGYSIFRLSNSQKNNFRTNPEDPSVKHLTYLQTKTGSRLITSGWWGIARHINYLGDWLQSWPYSLPTGIAGYQILSAGSNAPGAITMLDGREVVQGEARGWGIVFTYFYILYFAILLIHRDLRDDEKCSKKYGDDWEKYKKLVKWRIVPGIY