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eps15

Gene
eps15
Protein
Epidermal growth factor receptor substrate 15 homolog
Organism
Dictyostelium discoideum
Length
1196 amino acids
Function
May be involved in clathrin-mediated endocytosis.
Mass
131.394 kDa
Sequence
MRSEAQVPPAQKVYYEELFQIADVDKDGVIGLNDASFFRNSMLSNDILRDIWQLSDVNNGYLNIDDFFVALKLVSLAQMGAPVTLDSIKLIPVIPPPKLNDIPPLKNDWIISNGEKQNYIDLFNKYDEDGDGFILGSQAKTIFGTSGLPTKMLSHIWNLSDVSKDQKLDCQEFIMATFLIRSVLKGYELPNKLPESLITSSHYISSAGVPSPKIPEWLIPPPERIIYEDLFNKNQQGGIFTGSQAKVLFEKSGLSNQDLKLIWDLADHNQEQVLDKHKFVIAMFLISQRKKGKELPQSLPQLLLESSKSTFNPSSITSPPPQSSPQSSQLQQQPPQQQQQTGDSKYNINLNDLVSNTTPIGQPNIQPTTTTTTTPATASGGLNVSGLLSPPPQQQSPSIVGTPPSTITREGSFTFDNSGGGNNLLAKPPRSNSITRMNSFQHQLPQQQQQQVSPQSTISNTSIGSGSSSFLSTNATTSSPPPIPSTSSQPTSSNNSSITSNNNNPISPTSTNITQLFENIEKVKQQVFEQERIRQEEIQVKLNQELQLEAELKQQLAQEQQQLDEVRENVKEEEIKLSSIKADNQSLKEQISTARVDIKSLKSQLEQQSSLLREKSELFDEQNEALSHLNDDLKEKQQELQKNKQQIEQLLSSIESIKQNRTDVKNQISTVTKQLNDSKLELKQLAEEQKQQKQKLAEEQKQLQQLQQQQQQQATSKSLTSVKSDDNITFLSGINTNTTSTNTATSIPTASVSGNDNWDFFNSPPVKSSSSLPTSPFDDDKTFVPTFTTTTTTTNNNNNNNTINTSNGNLTFTSPVKSTVNQLKSSNSSVGGTGGSVSTRKLSGASVSSNNSFNDNTSIDTLNNHFGSDQFSFNSFGSNNLTAPPTTSSSTNKVQSDFFGVGGGNKDPFGGDSNNNPFGEESTSSIRDGGSETLSEAHTLFDKDPLFETNDAFQSSKDPFGQILFSNFTKDSFGGESVSNNSNNSSIISSNTIPSSNFTFNTNSTTTNNRQSPIDSDLFSDNQQQQQQQQQQQQQQQQQQQQQQQPTQSNQNNQSFTSNDSFDDFQTTPTPTNNNNNTTTTEFGVKFSDTTFGDSSNGDFDFGSNVFGQPSANDPFSSSIEPQHQPDTNNVSSDPFKGGFDDFGSAPFSFDNKFNEVVGDDSPSLTTATTTTTNDNDNGTFVFNDNNNNTPSPFDS

Gene
Eps15
Protein
Epidermal growth factor receptor substrate 15
Organism
Mus musculus
Length
897 amino acids
Function
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Mass
98.471 kDa
Sequence
MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLSKQEFFVALRLVACAQNGLEVSLSSLSLAVPPPRFHDSSSPLLTSGPSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSALLAHIWSLCDTKGCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNITGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTVKQRTSEVQDLQDEVQRESINLQKLQAQKQQVQELLGELDEQKAQLEEQLQEVRKKCAEEAQLISSLKAEITSQESQISSYEEELLKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQESQQEISSMQMRLEMKDLETDNNQSNWSSSPQSVLVNGATDYCSLSTSSSETANFNEHAEGQNNLESEPTHQESSVRSSPEIAPSDVTDESEAVTVAGNEKVTPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFTTSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAAASDSATDPFASVFGNESFGDGFADFSTLSKVNNEDAFNPTISSSTSSVTIAKPMLEETASKSEDVPPALPPKVGTPTRPCPPPPGKRPINKLDSSDPLKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA

Gene
EPS15
Protein
Epidermal growth factor receptor substrate 15
Organism
Homo sapiens
Length
896 amino acids
Function
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Mass
98.656 kDa
Sequence
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA