Protein
Ethylmalonyl-CoA/methylmalonyl-CoA epimerase
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Function
Promiscuous isomerase that catalyzes epimerization of both ethylmalonyl-CoA and methylmalonyl-CoA. Has thus a dual role in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source.
Similarity
Belongs to the methylmalonyl-CoA epimerase family.
Sequence
MIGRLNHVAIAVPDLEAAAAQYRNTLGAEVGAPQDEPDHGVTVIFITLPNTKIELLHPLGEGSPIAGFLEKNPAGGIHHICYEVEDILAARDRLKEAGARVLGSGEPKIGAHGKPVLFLHPKDFNGCLVELEQV