EPG5

Ectopic P granules protein 5 homolog

2579 amino acids

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391).

Belongs to the EPG5 family.

292.481 kDa

MAEAVKPQRRAKAKASRTKTKEKKKYETPQREESSEVSLPKTSREQEIPSLACEFKGDHLKVVTDSQLQDDASGQNESEMFDVPLTSLTISNEESLTCNTEPPKEGGEARPCVGDSAVTPKVHPGDNVGTKVETPKNFTEVEENMSVQGGLSESAPQSNFSYTQPAMENIQVRETQNSKEDKQGLVCSSEVPQNVGLQSSCPAKHGFQTPRVKKLYPQLPAEIAGEAPALVAVKPLLRSERLYPELPSQLELVPFTKEQLKILEPGSWLENVESYLEEFDSMAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLTSDCQNAKSRLWQFKEEQMSVQGICADQVKVFSYHRYQRVEMNENALVELKKLFDAKSEHLHQTLALHSYTSVLSRLQVESYIYALLSSSAVLRSSAIHQQGRASKQTESIPSDLCQLKECISVLFMFTRRVNEDTQFHDDILLWLQKLVSVLQRVGCPGDHLFLLNHILRCPAGVSKWAVPFIQIKVLHNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSERKPSSSGPGSGTWTLVDEGGEEDEDPETSWILLNEDDLVTILAQFPFHELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLETFNRARYRQFVKRIGYMIRMTLGYVSDHWAQYVSHNQGSGLAQQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLFYLMHQVESENLQQLSSSLQPAQCKQQLQDPEHFTNFEKCLSSMNSSEEICLLTTFAQMAQARRTNVDEDFIKIIVLEIYEVSYVTLSTRETFSKVGRELLGTITAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYLWQPSASEIAVIRDWLLNYNLTVVKNKLACVILEGLNWGFAKQATLHLDQAVHAEVALMVLEAYQKYLAQKPYAGILSESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDYGIQPNCPAVPFSVTVPDMTESPTFHPLLKAVKAGMPIGCYLALSMTAVGHSIEKFCAEGIPLLGILVQSRHLRTVVHVLDKILPLFYPCQYYLLKNEQFLSHLLLFLHLDSGVPQGVTQQVTHKVAQHLTGASHGDNVKLLNSMIQAHISVSTQPNEVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKAAFQLMQEDCIQKLLYQQHKNALGYHCDRSLLSSLVSWIVAGNITPSFVEGLATPTQVWFAWTVLNMESIFEEDSQLRRVIEGELVINSAFTPDQALKKAQTQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPIDGCIGRRFFQSPAHINLLKEMKRRLTEVADFHHAASKALRVPAEGSEGLPESHSGTPGYLTSPELHKELVRLFNVYILWLEDENFQKGDTYIPSLPKHYDIHRLAKVMQNQQDLWMEYLNMERIYHEFQETVGLWTQAKLESHSTPCSLSVQLDFTDPLLAKERVLSNLRKHEAPQPPLALHPTKPPVPVISSAVLLSQKDATQLVCTDLNLLQQQARTAALRESQQVALDGELLDTMPKQYVNREEQTTLHLECRGSSGKKCQGAAVVTVQFEGMHKNEAISQQLHVLRKEVKQLQAEAAKPPSLNIVEAAVHAENLITALVNAYKLQPTPGIQKVGISLFFTIVDYVSDETQRHPPTRQFFTSCIEILGQVFISGIKSECRKVLETILKNSRLCSLLSPFFTPNAAPAEFIQLYEQVVKFLSEDNSDMIFMLLTKFDLKQWLSATKPPLSDRTRLLESIHLALTAWGLEPDEDILMPFNLFCKHWTYLLLYQFPDQYSDILRLLMQSSAEQLLSPECWKATLRALGCCAPSCQQGAASTEGAVLPSSSDALLSDKQVMETIQWLSDFFYKLRLSKMDFKSFGLFSKWSPYMADVKTFLGYLVKRLIDLEMTCLAQDPTASRKTVLKSLHSVIIQLFKPWILVLEDNESSQQRHYPWLESDTVVASSIVQLFTDCIDSLHESFKDKLLPGDAGALWLHLMHYCEACTAPKMPEFILYAFHSTYRKLPWKDLHPDQMLMEAFFKVERGSPKSCFLFLGSVLCEVNWVSVLSDAWNSSPHPETRSMIVCLLFMMILLAKEVQLVDQTDSPLLSLLGQTSSLSWHLVDIVSYQSVLSYFSSHYPPSIILAKESYAELIMKLLKVSAGLSIPTDSQKHLDAVPKCQAFTHQMVQFLSTLEQNGKITLAVLEQEMSKLLDDIIVFNPPDMDSQTRHMALSSLFMEVLMMMNNATIPTAEFLRGSIRTWIGQKMHGLVVLPLLTAACQSLASVRHMAETTEACITAYFKESPLNQNSGWGPILVSLQVPELTMEEFLQECLTLGSYLTLYVYLLQCLNSEQTLRNEMKVLLILSKWLEQVYPSSVEEEAKLFLWWHQVLQLSLIQTEQNDSVLTESVIRILLLVQSRQNLVAEERLSSGILGAIGFGRKSPLSNRFRVVARSMAAFLSVQVPMEDQIRLRPGSELHLTPKAQQALNALESMASSKQYVEYQDQILQATQFIRHPGHCLQDGKSFLALLVNCLYPEVHYLDHIR

EPG5

Ectopic P granules protein 5 homolog

2579 amino acids

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391).

Belongs to the EPG5 family.

292.481 kDa

MAEAVKPQRRAKAKASRTKTKEKKKYETPQREESSEVSLPKTSREQEIPSLACEFKGDHLKVVTDSQLQDDASGQNESEMFDVPLTSLTISNEESLTCNTEPPKEGGEARPCVGDSAVTPKVHPGDNVGTKVETPKNFTEVEENMSVQGGLSESAPQSNFSYTQPAMENIQVRETQNSKEDKQGLVCSSEVPQNVGLQSSCPAKHGFQTPRVKKLYPQLPAEIAGEAPALVAVKPLLRSERLYPELPSQLELVPFTKEQLKILEPGSWLENVESYLEEFDSMAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLTSDCQNAKSRLWQFKEEQMSVQGICADQVKVFSYHRYQRVEMNENALVELKKLFDAKSEHLHQTLALHSYTSVLSRLQVESYIYALLSSSAVLRSSAIHQQGRASKQTESIPSDLCQLKECISVLFMFTRRVNEDTQFHDDILLWLQKLVSVLQRVGCPGDHLFLLNHILRCPAGVSKWAVPFIQIKVLHNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSERKPSSSGPGSGTWTLVDEGGEEDEDPETSWILLNEDDLVTILAQFPFHELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLETFNRARYRQFVKRIGYMIRMTLGYVSDHWAQYVSHNQGSGLAQQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLFYLMHQVESENLQQLSSSLQPAQCKQQLQDPEHFTNFEKCLSSMNSSEEICLLTTFAQMAQARRTNVDEDFIKIIVLEIYEVSYVTLSTRETFSKVGRELLGTITAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYLWQPSASEIAVIRDWLLNYNLTVVKNKLACVILEGLNWGFAKQATLHLDQAVHAEVALMVLEAYQKYLAQKPYAGILSESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDYGIQPNCPAVPFSVTVPDMTESPTFHPLLKAVKAGMPIGCYLALSMTAVGHSIEKFCAEGIPLLGILVQSRHLRTVVHVLDKILPLFYPCQYYLLKNEQFLSHLLLFLHLDSGVPQGVTQQVTHKVAQHLTGASHGDNVKLLNSMIQAHISVSTQPNEVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKAAFQLMQEDCIQKLLYQQHKNALGYHCDRSLLSSLVSWIVAGNITPSFVEGLATPTQVWFAWTVLNMESIFEEDSQLRRVIEGELVINSAFTPDQALKKAQTQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPIDGCIGRRFFQSPAHINLLKEMKRRLTEVADFHHAASKALRVPAEGSEGLPESHSGTPGYLTSPELHKELVRLFNVYILWLEDENFQKGDTYIPSLPKHYDIHRLAKVMQNQQDLWMEYLNMERIYHEFQETVGLWTQAKLESHSTPCSLSVQLDFTDPLLAKERVLSNLRKHEAPQPPLALHPTKPPVPVISSAVLLSQKDATQLVCTDLNLLQQQARTAALRESQQVALDGELLDTMPKQYVNREEQTTLHLECRGSSGKKCQGAAVVTVQFEGMHKNEAISQQLHVLRKEVKQLQAEAAKPPSLNIVEAAVHAENLITALVNAYKLQPTPGIQKVGISLFFTIVDYVSDETQRHPPTRQFFTSCIEILGQVFISGIKSECRKVLETILKNSRLCSLLSPFFTPNAAPAEFIQLYEQVVKFLSEDNSDMIFMLLTKFDLKQWLSATKPPLSDRTRLLESIHLALTAWGLEPDEDILMPFNLFCKHWTYLLLYQFPDQYSDILRLLMQSSAEQLLSPECWKATLRALGCCAPSCQQGAASTEGAVLPSSSDALLSDKQVMETIQWLSDFFYKLRLSKMDFKSFGLFSKWSPYMADVKTFLGYLVKRLIDLEMTCLAQDPTASRKTVLKSLHSVIIQLFKPWILVLEDNESSQQRHYPWLESDTVVASSIVQLFTDCIDSLHESFKDKLLPGDAGALWLHLMHYCEACTAPKMPEFILYAFHSTYRKLPWKDLHPDQMLMEAFFKVERGSPKSCFLFLGSVLCEVNWVSVLSDAWNSSPHPETRSMIVCLLFMMILLAKEVQLVDQTDSPLLSLLGQTSSLSWHLVDIVSYQSVLSYFSSHYPPSIILAKESYAELIMKLLKVSAGLSIPTDSQKHLDAVPKCQAFTHQMVQFLSTLEQNGKITLAVLEQEMSKLLDDIIVFNPPDMDSQTRHMALSSLFMEVLMMMNNATIPTAEFLRGSIRTWIGQKMHGLVVLPLLTAACQSLASVRHMAETTEACITAYFKESPLNQNSGWGPILVSLQVPELTMEEFLQECLTLGSYLTLYVYLLQCLNSEQTLRNEMKVLLILSKWLEQVYPSSVEEEAKLFLWWHQVLQLSLIQTEQNDSVLTESVIRILLLVQSRQNLVAEERLSSGILGAIGFGRKSPLSNRFRVVARSMAAFLSVQVPMEDQIRLRPGSELHLTPKAQQALNALESMASSKQYVEYQDQILQATQFIRHPGHCLQDGKSFLALLVNCLYPEVHYLDHIR

Epg5

Ectopic P granules protein 5 homolog

2572 amino acids

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located.

Belongs to the EPG5 family.

290.801 kDa

MAEAVKPRRAKAKASRTKGKEKKKHEALQTCDAGPLPETCREQESPCPASELKGDDLKSSADPQLHSDVCGWNESEMFDIPLTSLTIGDEGPPVQDTEDLKERGEVTAGDGDDEMELKVDPGDNVIAKGEPCKNFPEVEDHTLIQCGPPESTLQPDFPCTQQAVEGSHAREHPTRKQDEAALGCSKVFQNVSLHSSYEAKEVSQPPRVKKLYPELPAEIAEVPALVAVKPLLRSERLYPELPSQPEVTPFTKEQLKLLEPGSWLENVASYVEEFDNIAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLMSDCHSAKSRLWHFKDEQMAVQGICADQVKVYGHHHYQRVEMNENVLGELKKLFDAKSEHLHQTLTLHSYTSVLSRLQVESYIFTLLNSSAALRSLAVYQADQVPKLTESIPSDVCQLKECISVLFMFTRRVSEDAQFHEDILLWLQKLVSVLQRVGCPGDHFFLLNHVLRCPAGIRKWAVPFIQIKVLNNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSEWKPSSSGPASGNWTLVDEAGEEDEDPETSWILLNEDDLVTLLSQFPFQELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLDTFNRARYRQFVKRIGYLIRMTLGYVSDHWAQYVSHSTGAGLTPQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLLYLMHQVESGDLQQLCASLQPAECKRRLQDPEHFASFEKCLSSINSSEEICLLTAFAQMARARRTNVDEDFIKIIVLEIYEVSYVTLSTRETFSKVGRELLGAIAAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYLWRPSAPEIAVIRDWLLNNNLTAVKNKLACVILEGLNWGFTEQGTLHLDQALHTEVALLVLEAYQKYLAQKPYTGLISESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDFGRQNFPVIPFCSTVPDMTESSMFHPLLKAVKSGLPIGCYLALAVTAVGHSLEKFCAEGIPLLGVLVQSRHLRAVVHALDKILPVFYPYQCYLLKNEQFLSNLLLFLQLDSGVPQGVTQQVTHRVAQHLTGAVHGDNVKLLSSMIQAHICVSTQPDGVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKTAFHLMQEDCVQKLLYQQHKNALGYHCDRSLLSSLVNWIVAGNITPSFVEGLSTSTQVWFAWTVLNMESIFEEDSQLRRVVERELVINAFSPDQALKKAQVQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPVDGCIGRRFFQSPSHVNLLKDMKRRLTEVADFHYAASKALRVPAEGSEGTPEGQAGTPGFLTSPELHRELVRLFNVYVLWLEDENFQKGDTYIPSLPKHYDVHRLAKVMQNQQDLWMEYVNMERIQHEFQETVALWTQAKLESHAAPCSSSAQLDFTDPLLAKARVLSNLEKHEAPHPPLLLHPVRPPVPLIPSAALLTQKDSTQLMCTDLNLLQQQARSATLRESQQVALDGELLETMPKQYVNREDQATLHLECRGSSGKKCQGAAVVTVQFEGMNKNEAVSQQIHVLQKEVRQLQAEAAQPPALNVVEAAVHAENLITALVNTYKLQPTPGVQKLGISLFFTVVDHVSDETQRHPPTRQFFTSCIEILGQVFVSGTKSECRKLLQTILKNRRLCSLLAPFFTPNAAPAEFIQLYERVVTCLREDNSDVIFMLLTKFDIQQWLNSTKPPLSDRTRLLESIHLALTAWGLEPEEDILMPFNLFCKHWTHLLLYQFPDQYSDVLRLLVQSSAEQLLSPECWKATLRALGCYAPSSQQGAASVESSGLHSASRVLLSDKQVMETVQWLSDFFYKLRLSKLDFKSFGLFSKWSPYMADVKTFLGYLVKRLTDLEIASLSQDPTASSKEVLRSLHAQIIQLFKPWILVLEDAESSHQRHYPWLESDTAVASSIVQLFSDCVGSLHTSFKDRLLPGDEGALRLHLLHYCETCTAPKMPEFILYAFHSAYQRLEWKDLHPDQRLMEAFFKVERGSPKSCFLFLGSVLCRVNWVSVLSDAWNPSPLPETQSMAVCLLFMMVLLAKEAQLVDEPDSPLLSLLGQTSSLSWHLVDLVSYQSVLGYFSSHYPPSVVLANDCSSELIVKLLKVSAGLSAHADGRKHVDIVPKCQAFTHQMVQFLSALEQTGKITFPALEREISKLLDDIIIFNPPDMDSQTRHMALSSFFVEVLMMMNNAAVPTAEFLAVSIRTWIGQRVHGLIVLPLLTAACQSLASVRHMAEITEACIMAYFKESSLDQNLGWGPVLVSLQVPQLTARDFLEECLALGSCLTLYVYLLQCLNSEQTVKNDMKMLLVVSGWLEQVYPSSAQEEAKLFLWWHQILQLSLIQLEQNDSVLTESVIRILLMLQSRQSLMAEERLSSGILGAIGLGRRSPLSNRFRVAARSMAAFLLVQVPAEDQIRLKPSSELHLAPKAQQVLTALESMTLSKQYVEYQDQILHALQFIRHPGHCLQNGKSFLALLVNRLYPEVHYLDNIR

Epg5

Ectopic P granules protein 5 homolog

2572 amino acids

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located.

Belongs to the EPG5 family.

290.801 kDa

MAEAVKPRRAKAKASRTKGKEKKKHEALQTCDAGPLPETCREQESPCPASELKGDDLKSSADPQLHSDVCGWNESEMFDIPLTSLTIGDEGPPVQDTEDLKERGEVTAGDGDDEMELKVDPGDNVIAKGEPCKNFPEVEDHTLIQCGPPESTLQPDFPCTQQAVEGSHAREHPTRKQDEAALGCSKVFQNVSLHSSYEAKEVSQPPRVKKLYPELPAEIAEVPALVAVKPLLRSERLYPELPSQPEVTPFTKEQLKLLEPGSWLENVASYVEEFDNIAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLMSDCHSAKSRLWHFKDEQMAVQGICADQVKVYGHHHYQRVEMNENVLGELKKLFDAKSEHLHQTLTLHSYTSVLSRLQVESYIFTLLNSSAALRSLAVYQADQVPKLTESIPSDVCQLKECISVLFMFTRRVSEDAQFHEDILLWLQKLVSVLQRVGCPGDHFFLLNHVLRCPAGIRKWAVPFIQIKVLNNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSEWKPSSSGPASGNWTLVDEAGEEDEDPETSWILLNEDDLVTLLSQFPFQELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLDTFNRARYRQFVKRIGYLIRMTLGYVSDHWAQYVSHSTGAGLTPQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLLYLMHQVESGDLQQLCASLQPAECKRRLQDPEHFASFEKCLSSINSSEEICLLTAFAQMARARRTNVDEDFIKIIVLEIYEVSYVTLSTRETFSKVGRELLGAIAAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYLWRPSAPEIAVIRDWLLNNNLTAVKNKLACVILEGLNWGFTEQGTLHLDQALHTEVALLVLEAYQKYLAQKPYTGLISESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDFGRQNFPVIPFCSTVPDMTESSMFHPLLKAVKSGLPIGCYLALAVTAVGHSLEKFCAEGIPLLGVLVQSRHLRAVVHALDKILPVFYPYQCYLLKNEQFLSNLLLFLQLDSGVPQGVTQQVTHRVAQHLTGAVHGDNVKLLSSMIQAHICVSTQPDGVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKTAFHLMQEDCVQKLLYQQHKNALGYHCDRSLLSSLVNWIVAGNITPSFVEGLSTSTQVWFAWTVLNMESIFEEDSQLRRVVERELVINAFSPDQALKKAQVQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPVDGCIGRRFFQSPSHVNLLKDMKRRLTEVADFHYAASKALRVPAEGSEGTPEGQAGTPGFLTSPELHRELVRLFNVYVLWLEDENFQKGDTYIPSLPKHYDVHRLAKVMQNQQDLWMEYVNMERIQHEFQETVALWTQAKLESHAAPCSSSAQLDFTDPLLAKARVLSNLEKHEAPHPPLLLHPVRPPVPLIPSAALLTQKDSTQLMCTDLNLLQQQARSATLRESQQVALDGELLETMPKQYVNREDQATLHLECRGSSGKKCQGAAVVTVQFEGMNKNEAVSQQIHVLQKEVRQLQAEAAQPPALNVVEAAVHAENLITALVNTYKLQPTPGVQKLGISLFFTVVDHVSDETQRHPPTRQFFTSCIEILGQVFVSGTKSECRKLLQTILKNRRLCSLLAPFFTPNAAPAEFIQLYERVVTCLREDNSDVIFMLLTKFDIQQWLNSTKPPLSDRTRLLESIHLALTAWGLEPEEDILMPFNLFCKHWTHLLLYQFPDQYSDVLRLLVQSSAEQLLSPECWKATLRALGCYAPSSQQGAASVESSGLHSASRVLLSDKQVMETVQWLSDFFYKLRLSKLDFKSFGLFSKWSPYMADVKTFLGYLVKRLTDLEIASLSQDPTASSKEVLRSLHAQIIQLFKPWILVLEDAESSHQRHYPWLESDTAVASSIVQLFSDCVGSLHTSFKDRLLPGDEGALRLHLLHYCETCTAPKMPEFILYAFHSAYQRLEWKDLHPDQRLMEAFFKVERGSPKSCFLFLGSVLCRVNWVSVLSDAWNPSPLPETQSMAVCLLFMMVLLAKEAQLVDEPDSPLLSLLGQTSSLSWHLVDLVSYQSVLGYFSSHYPPSVVLANDCSSELIVKLLKVSAGLSAHADGRKHVDIVPKCQAFTHQMVQFLSALEQTGKITFPALEREISKLLDDIIIFNPPDMDSQTRHMALSSFFVEVLMMMNNAAVPTAEFLAVSIRTWIGQRVHGLIVLPLLTAACQSLASVRHMAEITEACIMAYFKESSLDQNLGWGPVLVSLQVPQLTARDFLEECLALGSCLTLYVYLLQCLNSEQTVKNDMKMLLVVSGWLEQVYPSSAQEEAKLFLWWHQILQLSLIQLEQNDSVLTESVIRILLMLQSRQSLMAEERLSSGILGAIGLGRRSPLSNRFRVAARSMAAFLLVQVPAEDQIRLKPSSELHLAPKAQQVLTALESMTLSKQYVEYQDQILHALQFIRHPGHCLQNGKSFLALLVNRLYPEVHYLDNIR

epg5

Ectopic P granules protein 5 homolog

2532 amino acids

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity).

Belongs to the EPG5 family.

286.825 kDa

MLHLQVKKERQSESVRQPSGSSKAVNEPEFTDVPLSLPHVPPDLNTAASQTSLDHHDKAENEQQHVLLCEKPEVVQKSTCHEDKEHELPSQDAAPRLDQTSVLAPSSQSDPKPLSAKLEPFSVPSIYPSIPASLSQPQLSEDSYSISYELLDGSLMPAASERLVAPAVLTLANQESSPPSLVPVEVVDVERSRERLYPELPKTCQSVKPFTSEQLRMWEPGSWLENVELHEAEFQNLAHQEGHELYELLLSYWRCRKQLTQAQTELQAANSDCKNVQNRLWSFKDERLSLQGICADQNKVYGYHCYQQVTLNEAALAELKHLFSAKAEILHQTVALHSYTSILSRLQVESYLYRLLSSNPTTKSVAVQDTSAGNPKSQPSSLQPLKESISVLFIFTRRVLDDSQFQADIHLWLQRLVSVLHQVGSTGDHLFILNHLLCCPAGVGKWAVPFLQIKVLDNPSGVYHFMQALAILMSPARHRPDFLGHMKPSDARGNNSLTEPASGNWTLVDEGGEEDEDPETSWMLLSEDDLVSLFSQFPFDELFKHLLGICSKGDYQPLATTSQKMMKIFAFASSLVELLAVGLQTYNRARYRQFVKRIGHMIRMTLCYVSDHWAQYISLTGVSRTTVQEQSFSMEKLQVEFDHLFLRAVLHVLKAKRLGIWLFMSEMPYGTLSSSMLWKIFYIMQCAETDGLEKLSCSLSAEDCIQRLRESSHQERFQLWLSEINSSDGICLLTTFAHMAQPRRTDVDPEFVRNIVLEIYEVSYVSVTTREIFSKVGRELLAAIAAAHPHIISVLLERLRETIERVGMVSLYLFKELPLHLWMPAQEEVGLIRDWLMNFSLTAVENRLACIILEGLNWGFQPNGCLILPAPLHSDVALLVIEAYQKYLTDKPYGGILSEGIKQVSYLANVVRLGQTPESSFNQWAWDIVLRLKLHANERSPQDAWCPLPSSSAPSVPEITDSPIMHPVFKAVKAGIPIGCFLAIEMTTIGHSLEKFCSEGISLLKTLIQSRHLRAAVHILENILPLVYNCQFYLLKNEQFLSCVQLFLQLDSGTQGVTQQVTQKVAQHLIGPATCENIKLLNSVIQAHVLESSRNGRVGAVAVLEFWLQVLTEQSLWYRDRAVLFLLDHMCRSAFLHQQEECLQKILYQQHKSALGYHGDKGLLSSIMGWIVAGNVTPSFIEGSSLTGEVWFAWMILNMETMFEEDSQLRRCVEHELLSNPACTPDQALKKAQVRLKLQVVPSLQRLMIYRWAQQALATPADHPILPLVWQKFFQLYLRQPGPEFGLEVKGCIGRRYFHSAAHLSLLKSLRQRLVEVSDFHHAASKALKVPCASGDSGDGLLTPGTPITQYMTSPDLHTEIVRLFTVFALWLDDENLQKQEIYLPSLPKQYDTHRLAKIMQRQQEVWMEHVDIERVQHELQEVLDLWSKVKSEPAVSQNSSSSIFTDFINPLAARERILTHLRKHDAPQGSLLPVPMKAPVPDIPTASLTDEKISTTLIQEDLTKLQHQAKLATVRETQQVALDNELLEVLPQLYINREDQLSMQLECRGKSGQPCQGPANITVKYSSMHKLEPVQNQIQSLKSDIKQLQADGIKAPPQSLAEAAVHTENFITALVNVFKQNPSPGVLKVGITAFYQIVSFVCEDTQRHPPTRQFFTSCIEILGQVFIRDVQSECKHMLKTILLNRRLCNLLSPYFTPNASPSELVSLYEEVVNTLHIDSGDVIFMLLTKFDLFQWLSTTQPPFSERSRLMTVIHQALCTCGLEPEPEVLMPFNIFCKHWTELLLYQFPDHYSDFLRLLMQSSSDQLLSPDCWRTSLKALGCSPQTKNKTNKSRSMLLSPQQVDETIEWLSKYFLKLRLSNGDFRSFGLLSKWGPYIEEVKVFWEDLITYVIDLELNHCGKEPVGSPRLLKALENLHRKMAKLFEPWILVLDTDNTSHPRCSPWLESDAAVAASLVGLYTRLTETLHEKFKDRLLPGQRGALWLHLMFYCETCTSPKMPEYLLYTYHTEYSRLPWKDLHPDQTLMNQFFNVERGSPKSCFVFMGELLCEVNWVSVLSDSLSPQLNPSTHTMVVSVLHLMVFLAKEDLSKPESSVLSLLDQSASLPWNLVDFSSYQNVTRYVSTHYPASLVLSHDTSSQQVVRLLRMAAGFEPTTQVLHHKDMTLKCQAFLHLMVQFLTSLDQNGNISLASLETEMEKLLENIVIFNPPETDLQQRHMATCSLFAEMLTLLNEAGISTAEGLGTKLHCWVEKRARGPLLLPLLTAACRCLASVRHMTRTTEACILSYFTDGCVDQYSGWGPILVSLQVPELTVEDFIQESLSLGSFLTLYVYILQRLNLEQTLLNEKKTLMLLNTWISQVFPSGPADEAKLFLWWHKFLELLQIQVDQEDACSLDTLILTLMAFQNRLVQLGEERLNSGILGAIGLGRKSPLSNRFRVVARSMSAFLLVQVPSENQLRLHPGTELQLSAKAQQALSALEAMASNKQYSELHVSVNQACQFIKYPNHCLRDANTLLTLLVNALYTDLHYLDIIR

epg5

Ectopic P granules protein 5 homolog

2532 amino acids

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity).

Belongs to the EPG5 family.

286.825 kDa

MLHLQVKKERQSESVRQPSGSSKAVNEPEFTDVPLSLPHVPPDLNTAASQTSLDHHDKAENEQQHVLLCEKPEVVQKSTCHEDKEHELPSQDAAPRLDQTSVLAPSSQSDPKPLSAKLEPFSVPSIYPSIPASLSQPQLSEDSYSISYELLDGSLMPAASERLVAPAVLTLANQESSPPSLVPVEVVDVERSRERLYPELPKTCQSVKPFTSEQLRMWEPGSWLENVELHEAEFQNLAHQEGHELYELLLSYWRCRKQLTQAQTELQAANSDCKNVQNRLWSFKDERLSLQGICADQNKVYGYHCYQQVTLNEAALAELKHLFSAKAEILHQTVALHSYTSILSRLQVESYLYRLLSSNPTTKSVAVQDTSAGNPKSQPSSLQPLKESISVLFIFTRRVLDDSQFQADIHLWLQRLVSVLHQVGSTGDHLFILNHLLCCPAGVGKWAVPFLQIKVLDNPSGVYHFMQALAILMSPARHRPDFLGHMKPSDARGNNSLTEPASGNWTLVDEGGEEDEDPETSWMLLSEDDLVSLFSQFPFDELFKHLLGICSKGDYQPLATTSQKMMKIFAFASSLVELLAVGLQTYNRARYRQFVKRIGHMIRMTLCYVSDHWAQYISLTGVSRTTVQEQSFSMEKLQVEFDHLFLRAVLHVLKAKRLGIWLFMSEMPYGTLSSSMLWKIFYIMQCAETDGLEKLSCSLSAEDCIQRLRESSHQERFQLWLSEINSSDGICLLTTFAHMAQPRRTDVDPEFVRNIVLEIYEVSYVSVTTREIFSKVGRELLAAIAAAHPHIISVLLERLRETIERVGMVSLYLFKELPLHLWMPAQEEVGLIRDWLMNFSLTAVENRLACIILEGLNWGFQPNGCLILPAPLHSDVALLVIEAYQKYLTDKPYGGILSEGIKQVSYLANVVRLGQTPESSFNQWAWDIVLRLKLHANERSPQDAWCPLPSSSAPSVPEITDSPIMHPVFKAVKAGIPIGCFLAIEMTTIGHSLEKFCSEGISLLKTLIQSRHLRAAVHILENILPLVYNCQFYLLKNEQFLSCVQLFLQLDSGTQGVTQQVTQKVAQHLIGPATCENIKLLNSVIQAHVLESSRNGRVGAVAVLEFWLQVLTEQSLWYRDRAVLFLLDHMCRSAFLHQQEECLQKILYQQHKSALGYHGDKGLLSSIMGWIVAGNVTPSFIEGSSLTGEVWFAWMILNMETMFEEDSQLRRCVEHELLSNPACTPDQALKKAQVRLKLQVVPSLQRLMIYRWAQQALATPADHPILPLVWQKFFQLYLRQPGPEFGLEVKGCIGRRYFHSAAHLSLLKSLRQRLVEVSDFHHAASKALKVPCASGDSGDGLLTPGTPITQYMTSPDLHTEIVRLFTVFALWLDDENLQKQEIYLPSLPKQYDTHRLAKIMQRQQEVWMEHVDIERVQHELQEVLDLWSKVKSEPAVSQNSSSSIFTDFINPLAARERILTHLRKHDAPQGSLLPVPMKAPVPDIPTASLTDEKISTTLIQEDLTKLQHQAKLATVRETQQVALDNELLEVLPQLYINREDQLSMQLECRGKSGQPCQGPANITVKYSSMHKLEPVQNQIQSLKSDIKQLQADGIKAPPQSLAEAAVHTENFITALVNVFKQNPSPGVLKVGITAFYQIVSFVCEDTQRHPPTRQFFTSCIEILGQVFIRDVQSECKHMLKTILLNRRLCNLLSPYFTPNASPSELVSLYEEVVNTLHIDSGDVIFMLLTKFDLFQWLSTTQPPFSERSRLMTVIHQALCTCGLEPEPEVLMPFNIFCKHWTELLLYQFPDHYSDFLRLLMQSSSDQLLSPDCWRTSLKALGCSPQTKNKTNKSRSMLLSPQQVDETIEWLSKYFLKLRLSNGDFRSFGLLSKWGPYIEEVKVFWEDLITYVIDLELNHCGKEPVGSPRLLKALENLHRKMAKLFEPWILVLDTDNTSHPRCSPWLESDAAVAASLVGLYTRLTETLHEKFKDRLLPGQRGALWLHLMFYCETCTSPKMPEYLLYTYHTEYSRLPWKDLHPDQTLMNQFFNVERGSPKSCFVFMGELLCEVNWVSVLSDSLSPQLNPSTHTMVVSVLHLMVFLAKEDLSKPESSVLSLLDQSASLPWNLVDFSSYQNVTRYVSTHYPASLVLSHDTSSQQVVRLLRMAAGFEPTTQVLHHKDMTLKCQAFLHLMVQFLTSLDQNGNISLASLETEMEKLLENIVIFNPPETDLQQRHMATCSLFAEMLTLLNEAGISTAEGLGTKLHCWVEKRARGPLLLPLLTAACRCLASVRHMTRTTEACILSYFTDGCVDQYSGWGPILVSLQVPELTVEDFIQESLSLGSFLTLYVYILQRLNLEQTLLNEKKTLMLLNTWISQVFPSGPADEAKLFLWWHKFLELLQIQVDQEDACSLDTLILTLMAFQNRLVQLGEERLNSGILGAIGLGRKSPLSNRFRVVARSMSAFLLVQVPSENQLRLHPGTELQLSAKAQQALSALEAMASNKQYSELHVSVNQACQFIKYPNHCLRDANTLLTLLVNALYTDLHYLDIIR