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end-3

Gene
end-3
Protein
Actin cytoskeleton-regulatory complex protein end-3
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
396 amino acids
Function
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
Similarity
Belongs to the END3 family.
Mass
44.974 kDa
Sequence
MPPKIEAQEIETYWNIFSARTNGGKFLTGEQAAPVLKNSGLRDDQLERVWDLADVDNDGNLDFEEFCVAMRVIFDLLNGEYADVPTTLPDWLVPESKAHLVQANRALTGKAPKFEQVEDEDDTPGLKDGFDWYMSPADKSKYEQIYQENRDMRGEVSFAALQDLYDSLSVPDTDIRSAWNLVNPSASSTINKDACLAFLHILNYRHEGFRIPRTVPASLRASFERNKITYNVNDPSQSRWAQKADDETSTGRKAKFGDQYLTRLGRSSFKTAGTDFSSEQTDDQWEEVRLKKQLAELDEKMAKVEEAANRRRGGKRDTKPALVKRELEQLLDYKRKELRDLEEGKGKAAAGGSLKSVADDLATVKEQVEGLEAHLRSRQDVLEQLKREIEEEKVGR