About Products Protein Database Contact

ema

Gene
ema
Protein
Protein CLEC16A homolog
Organism
Drosophila melanogaster
Length
1067 amino acids
Function
Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways (PubMed:20194640, PubMed:22493244). Required for endosome trafficking and maturation (PubMed:20194640). Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes (PubMed:20194640). In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy (PubMed:22493244). Essential for the recruitment of lva-positive Golgi elements to autophagosomes (PubMed:22493244). Likely to function by promoting membrane traffic from the Golgi complex to the developing autophagosomes (PubMed:22493244). Also regulates synaptic growth at the neuromuscular junctions (NMJ) by down-regulating BMP signaling (PubMed:20194640).
Similarity
Belongs to the CLEC16A/gop-1 family.
Mass
119.367 kDa
Sequence
MFRSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHDSLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMVHKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTISLNVYKVQNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHLDHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDIDIQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHSVFKEGAAEILNSYVEHREVVVPGFGEPDESLEQALDTVTGQSSSSSYALSEDSGVESSSPATTELDSQADAVEAEQIKLRNITDEEKQLLQKSSSSTKADFAEMAKPFLDTVLHALDCTENDYLALLSLCLIYAMSHNRGIKNEWFEQVLAKSTRGAFSYKTALIEHLLNIITQSSQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDLLFSARNQSMVVIRNFYKSEDIFLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYFLLRRTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLILVEPDAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHRGGVTHNRTPLLSAKFLFDDHIRCMAAKQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVGGTMVASSSGGSGNSSGSSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSGSNLRADHSDRERSPSVSMGSHSSSQSRENSQPRSTGNRSRESSPRMPRPRSEEIPLEDFQHSRNNSPHSRGNPSPASRSHTPIRVLHYDQLSGHSGSPREASLGGTNALLSQLNGLNREVLPTQSSEETSFIGSDGNEATGGSEGRRRGAIETV

Gene
ema
Protein
Protein CLEC16A homolog
Organism
Drosophila melanogaster
Length
1067 amino acids
Function
Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways (PubMed:20194640, PubMed:22493244). Required for endosome trafficking and maturation (PubMed:20194640). Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes (PubMed:20194640). In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy (PubMed:22493244). Essential for the recruitment of lva-positive Golgi elements to autophagosomes (PubMed:22493244). Likely to function by promoting membrane traffic from the Golgi complex to the developing autophagosomes (PubMed:22493244). Also regulates synaptic growth at the neuromuscular junctions (NMJ) by down-regulating BMP signaling (PubMed:20194640).
Similarity
Belongs to the CLEC16A/gop-1 family.
Mass
119.367 kDa
Sequence
MFRSRSWFGGPWGGRPKNRLSLEHLKYLYSILEKNTTVSESNRGLLVESLRCIAEILIWGDQHDSLVFDFFLEKNMLSYFLHIMRQKSGGSSFVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIMVHKFDFSDEDVMGYYILFLKTLSLKLNTHTIHFFYNEHTNDFPLYTEAIKFFNHPESMVRIAVRTISLNVYKVQNPSMLRFIRDKTAAPYFSNLVWFIGKHILELDTCVRTDIDHQSNQKLSNLVAEHLDHLHYLSDILLLEIKDLNAVLTEHLLHKLFVPLYIFSLTPAPPPPSLAVVTQNLAAVLNRNVDIDIQEMHNPRVSSIVALFLLSLVFLVVSHAPLVHALAWVILNGDHSVFKEGAAEILNSYVEHREVVVPGFGEPDESLEQALDTVTGQSSSSSYALSEDSGVESSSPATTELDSQADAVEAEQIKLRNITDEEKQLLQKSSSSTKADFAEMAKPFLDTVLHALDCTENDYLALLSLCLIYAMSHNRGIKNEWFEQVLAKSTRGAFSYKTALIEHLLNIITQSSQPSSRIRLITVEIALELLVTFTRPSSDDSRCITAAQQDLLFSARNQSMVVIRNFYKSEDIFLDLFEDEYNEMRKAQLNVEFLCMDSTILLPPTGTPLTGINFTRRLPCGEVEKARRAIRVYFLLRRTCQKFLNEKESLLPLTNVVNLVQVENVLDLNNSDLIACTVVAKDSSKQRRFLVIDALQLILVEPDAKLLGWGVAKFVGFLQDVEVQGDKDDSRCLHITVHRGGVTHNRTPLLSAKFLFDDHIRCMAAKQRLTKGRSKARQKKMYQIAQLIEIPGQMDSPVYAVGGTMVASSSGGSGNSSGSSSRSSHHRPMFSTANRVPGFAAVLRGSNSAGVSRTQMAPNRSIEGIRNESAGRSRRRSPSSTSGSNLRADHSDRERSPSVSMGSHSSSQSRENSQPRSTGNRSRESSPRMPRPRSEEIPLEDFQHSRNNSPHSRGNPSPASRSHTPIRVLHYDQLSGHSGSPREASLGGTNALLSQLNGLNREVLPTQSSEETSFIGSDGNEATGGSEGRRRGAIETV