Function
Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof (PubMed:19591818, PubMed:21829390). During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage (PubMed:9224715, PubMed:16303852, PubMed:11259601). The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres (PubMed:9224715). Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion (PubMed:16303852). Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif (PubMed:21829390). Probably represses expression of eff-1 to prevent fusion of seam cells with the hypodermal syncytium (PubMed:21829390). Involved in regulating expression of elt-3, a probable downstream target in hypodermal development pathways, in dorsal and ventral hypodermal cells (PubMed:16303852, PubMed:11259601). During postembryonic development, has a role in sperm development (PubMed:19591818). Specifically, binds the bipartite consensus sequence 5'-AGATCTx(8)GATAA-3' found in genes with sperm-specific expression (PubMed:19591818). Furthermore, regulates timing of developmental steps, possibly in parallel with daf-12, by controlling the expression of the let-7 family of miRNAs which in turn determines the transcription of heterochronic genes such as lin-41 (PubMed:25816370).
Sequence
MDYEGKPVEFTLGTSSGGASLAPTSSTTAASIAPFSYNTSATNYYNTTPSSYPMFLNYQYAGGTTVTTDMDAFSGMDMSMNNGVFGTQNNPSYFYPTTQLNTYGYDTLAAATTASGITVNNNQLNVNIVQGNGTIVPQPITQNIISTVSNVQSSVPINNSQPLTPTGLAGCSTSSGSSSASSSSANSTSTPKNTISKANRSSGGANNSQFSTEDRECVNCGVHNTPLWRRDGSGNYLCNACGLYFKMNHHARPLVKPKKRQQNAQKRTGIECVNCRTNTTTLWRRNGEGHPVCNACGLYFKLHKVERPITMKKDGIQTRNRKLSAKGSRRMKKENGGTPTSMGMPTTSSSISSGIELDQSGVWGMKNTQPMLMTPTAYAFPASNFYFNSIEDQLEYKTCPPMMVDFGGQMKNLNLN