Protein
ELMO domain-containing protein A
Organism
Dictyostelium discoideum
Function
Functions as a negative regulator of actin polymerization. Modulates actin/myosin II at cortex actinomyosins to prevent excessive F-actin polymerization around the cell periphery, thereby maintaining proper cell shape during phagocytosis and chemotaxis.
Sequence
MKIKVTFQERIIEHNFETEITNLQQVTQKLCSLFLITNYYSYSLFLSSGQLVDNINLIDEGSEIIIKHLNRLGTISIGSGYSNSVVGTTNNNAPSSPSSSININGQQIQQQIQQQIQQQQQQQQQQQQQVQLSPDTLINNLLNNLKDNTFKKKAFFDLKDLKEEILIKKFVEKNGIEVIVCQLKELTGNTLSYALSALQTIMSYEFTITSMTSTDTASLITQLLPLTENTSNPSISKTSLSLLCLFLNQSNNLNFKQFSSTLVLEYNEKTKRNYNHTLVQLLSSSNTVDVQLNALTLINIIIGKTMSTTIPGLENGSVTGGENGFNKLLKELDEYEINQKLKKLVESIIVAPELKRQLYIYQRHRFQVITNRKNVTFNKESSEHDALLMKLWSLTYPGVKLESRVSEQWKQMGFQGTDPCTDFRAMGIWGLDNLIYFAQNYNEKFRKIVNSQIDRKEREYPTATAGIVLTFELYNSIFKMGTPNLNPYNSTTSNTTSNTTSTTNIDDLPFFPLFFSHPHAFEEVYCTTFQILDSTWDDMNGTYMHFQKIMSSVKNLIITALESKPTTLEAFDWKCQKNTKNSNGGTNSNQNNSSSNLLLSNFANGSSLLSLLNDLSSSSRDDMKKLLTGVNYQVLDLIKSQKISYFQEGFQFKLHKQLKTKQSLPLNWIFIRLFNNNNNNNNNNENCSYEIQYCFLSTELNQPPLPNQSIPTNYNTIKISDLFFNGESTNSNNKKKDKSLSYFNISIKDEQIQSLIQNQLPLSNLNNSSNSLQLDSSTSMNSIKDSIINISSSNNNIKDNLTNNNTNTNTNNTNNNTSNGNGNSNSVSMSSININNSGQLSPNTTSPILIPQQQQQQPQSSSLSVQHQQSSTPTPSSPVLLSSPSLQSSSSSSSSSSNPNLFTIDLISSNRDDVSNFWDSIKLLSGQEIKSQEGLDDYHSLLSINTSVKLLDLDGIDIPKETPQIPILPDNFDFRTV