Protein
8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase
Organism
Streptomyces olivaceus
Function
O-methyltransferase involved in the biosynthesis of the permethylated L-rhamnose moiety of elloramycin, an antitumor polyketide. Mediates the methylation of the hydroxy groups at the 4'-position after the sugar moiety has been attached to the aglycon.
Similarity
Belongs to the methyltransferase TylF/MycF family.
Sequence
MTEDARDLYLDLMKKVLTNLIYRDAPIQTFVYDGEPDADPRLLGRDWPSVAHTMVGLKRLDNLQYCVETVLADGVPGDLVETGVWRGGSSIFMRAVLRAHGDTARRVWVADSFEGMPEVGADSHAVDREMRLHEHNGVLAVPLEQVRANFERYGLLDDQVRFLPGWFKDTLPGAPTGRLAVIRLDGDLYESTTDALENLMPRLSPGGFVIIDDYAIDACRDAVHDYRGRYGISDPISEIDGTGVFWRHTAASARSLQPATV