Protein
Laminin-binding fimbrial subunit ElfA
Organism
Escherichia coli O157:H7
Function
Part of the elfADCG fimbrial operon, which could be required for adherence to host epithelial cells. ElfA is an accessory colonization factor that contributes to adherence of bacteria to human intestinal epithelial cells and to animal intestinal tissue in vitro. Binds specifically to laminin, but not to fibronectin or collagen type IV.
Similarity
Belongs to the fimbrial protein family.
Sequence
MITMKKSVLTAFITVVCATSSVMAADDNAITDGSVTFNGKVIAPACTLVAATKDSVVTLPDVSATKLQTNGQVSGVQTDVPIELKDCDTTVTKNATFTFNGTADTTQITAFANQASSDAATNVALQMYMNDGTTAIKPDTETGNILLQDGDQTLTFKVDYIATGKATSGNVNAVTNFHINYY