Protein
Ectoine dioxygenase
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function
Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.
Similarity
Belongs to the PhyH family. EctD subfamily.
Sequence
MTTITDLYPSRGAAEVSVPRQDPVLWGTPDTPGPITAADLQSYEHDGFLAVPQLIGDDEVALYHAELERLIHDPAVRADERSIVEPQSQEIRSVFEVHKISEIFAQLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNMRTVSVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGTPSDEALTKFADRHGIRLFTGRAGSATWFDCNCLHGSGDNITPFPRSNVFIVFNSVENTAVEPFSAPVRRPEFIGARDFTPVR