eccB1

Gene

eccB1

Protein

ESX-1 secretion system ATPase EccB1

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

480 amino acids

Function

An ATPase (By similarity). Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).

Similarity

Belongs to the EccB family.

Mass

51.093 kDa

Sequence

MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMGPWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP

Protein

ESX-1 secretion system ATPase EccB1: eccB1

Gene

eccB1

Protein

ESX-1 secretion system ATPase EccB1

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

480 amino acids

Function

An ATPase (PubMed:26396239). Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:16368961).

Similarity

Belongs to the EccB family.

Mass

51.093 kDa

Sequence

Protein

ESX-1 secretion system ATPase EccB1: eccB1

Gene

eccB1

Protein

ESX-1 secretion system ATPase EccB1

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

479 amino acids

Function

An ATPase (shown for residues 72-479) (PubMed:26396239). Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (PubMed:15687187). Plays a role in DNA conjugation, in both donor and recipient strains (PubMed:15314236).

Similarity

Belongs to the EccB family.

Mass

51.022 kDa

Sequence

MAGFRLTTKVQVSGWRFLLRRVEHAIVRRDTRMFDDPLQFYSRAVFAGVVVSVLICLGAALMAYFKPLGKQGSDQLLVDRTTNQLYVMLPGSNQLRPVYNLTSARLVLGNASNPVAVKSEELNRISKGQSIGIPGAPYATPTGTPASQWTLCDTVAKPDSSAPKVETSILIRTLAIDSGVGPIRADQGMLVSYEGANWLITEGGRHSIDLADRAVTSAVGIPVTAKPTPISQGLFNALPNRGPWQLPQIPAAGAPNSVGLPENLVIGSVFRTATESDPQHYVVLPDGVARVNNTTAAALRATNSYGLMQPPAVEASVVAKIPEQVYVSPLPDQPLDVLLRQDSPVLCWSWQREPGDQAPKTTVIAGRRLPLPANAIGTGIDQIGGDSTVYIEGGQFVRLQSPDPRVGESMYYIDPQGVRYGIANDDAAKNLGLAGPVNAPWQVVGLLVDGPVLSKEAALIEHDTLPADPNPRKVASGEG

Protein

ESX-1 secretion system ATPase EccB1: eccB1