eccA1

Gene

eccA1

Protein

ESX-1 secretion system protein EccA1

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

574 amino acids

Function

Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (PubMed:15687187). Plays a role in DNA conjugation, in both donor and recipient strains (PubMed:15314236, PubMed:18554329). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

62.148 kDa

Sequence

MVNHLAGMFGSAVGMMSNSRARALEIFTEITNYDESACDAWVGRIGCGDTDRVTLFRAWYSRSNFGQLAGAAEISMNGVGARIPIGGIYSRDITYPINSPLAITMGFAVHEASEGNYTDAMEALEDAPAAGSEHLVSWVRAVIYGAGQRWTEVIDQVRGAERWPDKFLAAAAGVAHGVAAANLGLFTEADRRLTEANDTPVAQACAPVIAWYLAMARRSQGNEESAQVLLEWLQANFPEPKVTAALRDPAYRLETTTAEKIAARSDPWDPSSVVADTSARDKLLVEAQAELDRQIGLGRVKEQIEAYRAATQMARIRAARGMKVAQTSKHMIFAGPPGTGKTTIARVVANILAGLGVIAEPKLIETSRKDFVAEYEGQSAVKTSKTIDRALGGVLFIDEAYTLVQERNGQTDPFGAEALDTLLARMENDRDRLVVIIAGYSNDIDRLLEVNDGLRSRFATRIEFDSYSPDEIVEISKVIATANDSRLDDTAAKRVLEAATTLSQRSLNGKPALDIAGNGRYARQLVEAGEQNRDMRLARSLDFDSLGVDQLSEINGDDMAAAIASVHSRLNIGE

Protein

ESX-1 secretion system protein EccA1: eccA1

Gene

eccA1

Protein

ESX-1 secretion system protein EccA1

Organism

Mycobacterium smegmatis (strain MKD8)

Length

574 amino acids

Function

Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in both donor and recipient strains (PubMed:18554329). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

62.148 kDa

Sequence

Protein

ESX-1 secretion system protein EccA1: eccA1

Gene

eccA1

Protein

ESX-1 secretion system protein EccA1

Organism

Mycobacterium leprae (strain TN)

Length

573 amino acids

Function

Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

62.342 kDa

Sequence

MIDRLGSLFESAASMLPMSEARSFELFTEITNYDETACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQIPMTTLNARVPIGGLYGDITYPVTSPLAITMGFAACEAAQGNFADAMEAIDATSITGSEHLVAWLKAVVYGAAERWTDVIDEVKGAGKWPDKFLAGAAGVAHGVAAANLGLFTEAERRLTEANDSPAGEACARSIAWYLAMARRSQGNEDAAVALLEWLQTTHPESKVSAALKDPSYRLTTTTAEQIAARADPWDPSSVVTDNSDRDRLLTQAQAELDRQIGLTRVKTQIERYRAATMMAKVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVISEPKLVETSRKDFVAEYEGQSAVKAAKTIDLALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPDELLEIAKVIATDADSSLSAEASKNLLEAAKQLAQRTLRGRPALDVAGNGRYARQLVEAAEQCRDMRLARGVDIEQLDVDRLQEINGSDMAEAIATVHAHLNIRE

Protein

ESX-1 secretion system protein EccA1: eccA1

Gene

eccA1

Protein

ESX-1 secretion system protein EccA1

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

573 amino acids

Function

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates.

Similarity

Belongs to the CbxX/CfxQ family.

Mass

62.426 kDa

Sequence

MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE

Protein

ESX-1 secretion system protein EccA1: eccA1

Gene

eccA1

Protein

ESX-1 secretion system protein EccA1

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

573 amino acids

Function

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:18974091, PubMed:16368961). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (PubMed:18974091).

Similarity

Belongs to the CbxX/CfxQ family.

Mass

62.426 kDa

Sequence

Protein

ESX-1 secretion system protein EccA1: eccA1