Protein
Serine/threonine-protein kinase dyf-5
Organism
Caenorhabditis elegans
Function
Serine/threonine-protein kinase which is required for ciliogenesis. Regulates the length and the morphology of sensory neuron cilia. In addition, plays a role in the anterograde intraflagellar transport (IFT) in the cilia by regulating the undocking of kinesin-II motor complex (composed of klp-11, klp-20 and kap-1) before reaching the distal segment and the docking of kinesin motor osm-3 onto IFT cargos.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. RCK subfamily.
Sequence
MSSAVKLADRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLREVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQQVVATPMEQVVNTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYFQVAEKLGAPVVSQPAPGSIRKTSAASVKSDTKAMTAKAAKKDYIGSENVSPQQPAKVIDRHINRNLPLNKETLFEKSDNKPLGPTKSNEAKPTAKEIYLSKSKYVPGQVSKDTHQNQIMTTNGLTGTTKTTTFSAKKEGRTAVQTRFEYAYGYIPSFGARQTGPTVSNQTNNHSANNSHSPNKMSNTGRVDWAAKYVK