dpyd-1

Gene

dpyd-1

Protein

Dihydropyrimidine dehydrogenase [NADP(+)]

Organism

Caenorhabditis elegans

Length

1059 amino acids

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil.

Similarity

Belongs to the dihydropyrimidine dehydrogenase family.

Mass

115.301 kDa

Sequence

MTPKPNTTSPTNNLPLLSKDSPDIESLLILNPKVQDKANAVPSAVTKKNKHNWKRNEEKGCGSTCGESKLKNDFRDIKHTTLSERGALKEAMRCLKCADAPCQKSCPTQLDVKSFITSISNKNYYGAARQILSDNPLGLTCGMICPTSDLCVGSCNLQASEEGAINIGGLQQYACDVFKQMNVRQIVSKEVRENRNASHKEQVALIGCGPASISCASFLARLGYTDITIYEKRAYIGGLSSAEIPQFRLPYDVVDFEIQLARDIGVQIETNRPLGKDGLTLAKLKEQGAAAVFIGIGNPEPKIDPLFEGLTIENGFYTSKNYLPAVAAASKPGMCGCKRTPLPTMRGRVVVLGAGDTAMDCATSALRCGASRVTIAFRKGFTGIRAVPEEMEAAKEEKCEFLPFSAPRKINVKDGRIVSIEFNKTEQDDNGKWYEDEEQIVILKCDYVISAFGSTLKEDAVLSALQPCQLNKWGGIEVDSTTQQTSEKWVFAGGDVAGVAETTVESVNDGKIAAWNMHRYIQSLHGNQVSETPELPQFFTPIDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVSPRIVRGSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIASIMCVYNKADWIELATKSEEAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPFFPKMTPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGSTKRTTYGGMSGSAIRPIAMKAVSSIANELDGFPIMATGGIESAETGLGFLMAGASVLQVCSAVQNQDFTVVDDYCTGLKALLYLSGAESLKNWDGQSPPIEKHQKGKPILLQGQKKMPFFGKYRDEREKLEAIKLSESNLLDTENYHFASRPDTQVSRVPTVEDVIGKALPRIGPYVTLDNQEQKVAIIDDDMCINCGKCYMTCNDSGYQAITFDPVTHQPHVTEDDCTGCTLCYSVCPIPECIEMVPRTGPWKAPKRGVKPSVEPGTPKVVKVDQRGRVILDTTGGMQ

Protein

Dihydropyrimidine dehydrogenase [NADP(+)]: dpyd-1

Gene

dpyd-1

Protein

Probable dihydropyrimidine dehydrogenase [NADP(+)]

Organism

Caenorhabditis briggsae

Length

1053 amino acids

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (By similarity).

Similarity

Belongs to the dihydropyrimidine dehydrogenase family.

Mass

114.672 kDa

Sequence

MTPKPNTSNPNVGLPLLSKDSPDIESLLILNPKVQSKANAVPSAVTKKNKHNWKRNEEKGCGASCGESKLKNDFRDIKHTTLSERGALKEAMRCLKCADAPCQKSCPTQLDIKSFITSISNKNYYGAARAILSDNPLGLTCGMICPTSDLCVGSCNLQASEEGAINIGGLQQYACDVFKQMNVRQIVSKEVRENRNASHKEQIALIGCGPASISCASFLARLGYTDITIYEKRAYIGGLSSAEIPQFRLPYDVVDFEIQLARDVGVKIETNRSLCKEDITLDKLKSQGAAAVFIGIGNPEPKIDPLFEGLTIENGFYTSKNYLPAVAAASKPGMCGCKRTPLPTMRGRVVVLGAGDTAMDCATSALRCGASRVTIAFRKGFTGIRAVPEEMEAAKEEKCEFLPFSAPRKINVKDGRIVSIEFNKTEQDDNGKWYEDEEQIVILKCDYVISAFGSTLKEDTVLSALQPCKLNKWGGIEVDSTTQQTSEAWVFAGGDVAGVAETTVESVNDGKTLMDLTFKIQIAAWNMHRYIQAKHGNVLGETPELPKFFTPIDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTNVSPRIVRGSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVVASIMCVYNKEDWIELATKSEAAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPFFPKMTPNITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGNTKRTTYGGMSGSAIRPIAMKAVSSIANELDGFPIMATGGIESAETGLGFLMAGASVLQVCSAVQNQDFTVVEDYCTGLKALLYLSGAESLKEWDGQSPPVEKHQKGKPILLQGQKNMPFFGKFRDEREKLEALKLSESNLLDTDNYHFASRPDTQVARVPTVEDVIEHEVAIIDHDMCINCGKCYMTCNDSGYQAITFDAVTHQPHVTEDDCTGCTLCYSVCPIPECIQMVPRKGPWKAPKRGVKPTVEPGTPKVVKVDQRGRVILESTGGMQ

Protein

Probable dihydropyrimidine dehydrogenase [NADP(+)]: dpyd-1

Gene

dpyd-1

Protein

Probable dihydropyrimidine dehydrogenase [NADP(+)]

Organism

Caenorhabditis briggsae

Length

1053 amino acids

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (By similarity).

Similarity

Belongs to the dihydropyrimidine dehydrogenase family.

Mass

114.672 kDa

Sequence

Protein

Probable dihydropyrimidine dehydrogenase [NADP(+)]: dpyd-1