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dph-5

Gene
dph-5
Protein
Diphthine methyl ester synthase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
287 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
Similarity
Belongs to the diphthine synthase family.
Mass
32.213 kDa
Sequence
MLYLVGLGLSDETDITVKGLEVVKKAERVYLEAYTSILLVDQATLESYYGRPIVVADREMVESNSDEILRDADKVDVAFCVVGDPFGATTHTDLVLRARELGIQVRTVPNASIMSGIGAAGLQLYNFGQTVSMVFFLDNWRPASFYDRIKENRSIGLHTLVLLDIKVKEQSLENMARGRKIYEPPRYMTVGTCAQQMLEIEEEKQEGVYGPESLAIGCARVGGKTEKFVSGTLKELCDADDLLGPPLHSLILLGRRTHELEHDFVREFAVNKENWDRIWKAEYCGKQ