Protein
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
Similarity
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
Sequence
MEDDRAQVDLGIAADIDEMNPPPPPSVQQKQPKKRFLGRQSAAAGKSSSSSSNSTSQPAGANTSIEDSGAIQVAQPRRAPRMLNQVPDSILHDAALNEAIALLPSNYSFEIHKTIHRIRTLDAKRVALQMPEGLLLFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARAMGCDLLVHYAHSCLIPVDVTKIKTLYVFVDISIDTSHLLATLERNFAPGKSIAMVGTIQFNATIHGVRSTLQKAGYEVIIPQIAPLSKGEILGCTSPNLSQFLTSSGKQVDMILYLGDGRFHLESIMIHNPSIPAYRYDPYSRKLTHETYGHEEMQDVRRSAIRQAKTAKKWGLILGSLGRQGNPNTLGLIEEKLKANGTPFVNFCLSEIFPGKLAMMSDVECWVQVACPRLSIDWGYAFPRPLLTPYEALIALEEKEDWGKGAYPMDYYGREGLGRTKPAAMEV