Protein
Vacuolar-sorting protein dot2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Negatively regulates meiotic spindle pole body maturation via indirect regulation of the pcp1 gene. Required for efficient entry into pre-meiotic S phase.
Similarity
Belongs to the SNF8 family.
Sequence
MRKRIGIGALNDDEYLKQYEEVGNELIEQQSDEIASQLSTFQEALKTFAREHATEIKQNSQFRNTFVKLALKIGLDPFVSGSDESAWAAVGMNEFYYQVAVRVIEVCYATQMENGGLLSVSQVCRFLNEENEAFGHEWLRETDVVRAVDSLAPLGPGFVLEKIAGKQYIRSLPLELNTDQNVVLEAVEILGYVTISILRDNYAWERSRCIQVLNDLVSKSLLWIDSQGVEMAYWGASNLIDDQAQRFLYENF