Function
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex (PubMed:9065698, PubMed:10549280, PubMed:27253064, PubMed:25422373). In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route (PubMed:25422373). Required for the biogenesis of eye pigment granules (PubMed:10549280). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599).
Sequence
MDTSMPNQPKFLPRIEHNSSGATANSYVATASGNPFETDEEDEIFSRHKMVLRVPSNCTGDLMHLAVSRNWLVCLLGTPERTTLLRFFLPRAIPPGEAVLEKYLSGSGYKITRMFLDPTGHHIIIALVPKSATAGVSPDFLYIHCLESPQAQQLKVRRIEKFKDHEITAVAFNPYHGNESSTGPILLGTSRGLIFETELNPAADGHVQRKQLYDLGLGRPKYPITGLKLLRVPNSSRYIIVVTSPECIYTFQETLKAEERSLQAIFAGYVSGVQEPHCEERKTDLTFSQLRFFAPPNSKYPKQWAWLCGEGIRVGELSIEANSAATLIGNTLINLDFEKTMHLSYGERRLNTPKAFVLTEYHAVLLYADHVRAICLLNQEQVYQEAFDEARVGKPLSIERDELTGSIYVYTVKTVFNLRVTREERNVWRIYLDKGQYELATAHAAEDPEHLQLVLCQRADAAFADGSYQVAADYYAETDKSFEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPMETDELDEDKMNIIKALVIWLIDLYLIQINMPDKDEEWRSSWQTEYDEFMMEAHVLSCTRQNRETVRQLIAEHADPRNMAQFAIAIGDYDEVVAQQLKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTVDALMAQGSRLEVEKLVPTLIIMENREQREQTQRYLEFAIYKLNTTNDAIHNFLLHLYAEHEPKLLMKYLEIQGRDESLVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLALTFDMKLAKETASRPSDSKIRRKLWLRIAYHDIKGTNDVKKALNLLKECDLLRIEDLLPFFADFEKIDNFKEAICDALRDYNQRIQELQREMAETTEQTDRVTAELQQLRQHSLTVESQDTCEICEMMLLVKPFFIFICGHKFHSDCLEKHVVPLLTKEQCRRLGTLKQQLEAEVQTQAQPQSGALSKQQAMELQRKRAALKTEIEDILAADCLFCGLLISTIDQPFVDDWEQVNVEWE