dokA

Hybrid signal transduction protein dokA

1671 amino acids

Part of the osmoregulatory pathway which leads to the increase of intracellular cAMP concentration in response to hyperosmotic stress. Thought to negatively regulate the rdeA-regA pathway by acting as a phosphatase towards the HPt protein rdeA. Has probably no histidine kinase activity.

186.136 kDa

MSSPHIELHSQRTLSPQPSSNNFELTGNKSCALSASLNGSIDDLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDGDKNDKKLLIITNAPTPPLTPPQPTKTQQTLLELNQKFQEQQQQQQQQQQLQKQNKQQQSQKQQEEPPSSQQEEPPLSQQQQEQEQEQEQEQEQEEQSKQKIEGKGGGGEEEECEGGGGGEGEGEEQFKEGDEEEHEGIEIDPNLPTTGYTGKRRSSLQINEASPKLIQTPSVDRTLCILDSLPCPIFQIGIIENTENGNITLTGFANERLTTLLSCSSNLLVDSLKSIPSPHYNTVPSLESCNSIPINNLAPGLLPNTDPTKILDPYISLYNKKQLKERYSNNNNNTNTNNNNNNNNNNNNNNNNNNNNNNNDTTTTTTTTTTTTTTTTTTTTTTTTNESDNNNNNNNNNNNNNNNNNNNNNNNEEIKQNTKEGEEILHESTNSTGTGNSISRPNSILQCILDSFHEQKTITEKVLLSNFLIRQQYKSRATIKPFPDGCICIFEYIENINLNYQQPPTSLNDRINSTNKLTNEMELLSLSPDSNHQHVQKLHNHNHNHHNHNHNNTTQRASSTDSPFIHSVSANSLSSMSSNSSVTSACASLSSNSSSNSNNNSNNASSSNCSSNANSNNTNSSSSNCCCCCNNNNNNNTSSTSSTISSASSTKSKSYLHQQHKNSKVYSTLLNSFENLSFLLKSTPIIIWRADHNGEMVFFKKSDEIPIDEKKVVGNNFQDFLQWVPQTYRTNFQEMFQNSLKCGKIFEFLFWFQTPQNYVQLFKIAGYPIFHIDGKDCIASKRYLIGWLGVTYNYLINDGAEISIKGSANLDSMYEKFKIIYEMPNIERTKLTNNGISSGGDITNANNNGGSSESSNKILEKKKHLISEAEKECFLKCKETYNILFKLSLLGVMFSTFKGIILDANDMLLQTIGYTRGDLENGKIDWMLLTPPEHFEISARALQELKAKRWCQPIEKAYIHKSGKRVPVLITSAMIDGSTEQCITFVFDLSRYRQAEMAAIEATRLKTQFITNISHELRTPCHGIVGMSQLLLDSQLTNTQRDNIDSIKRSTDSLISLINDILDFSKLEYGKVTLENESFELLPMIEEVLDSQATAANRKGIDLIFVMGRDYPVPPVIFGDRNSLKKVLLNLVGNAVKFTETGFVLLEISTDYESGDQISLRFTVKDSGIGIPENKIEQIFVPFGQIDGSFSRKYGGSGLGLSFCKELVALMGGYIRVESGDQEGGKGTTFWFAIKVSISSPSYLPNSVPAANQFFYPEYRPSHYNNVIGNGDSPKNVLIIESNQMVIMSIQSILLSMKCECISASKAITALDLLESSKSTENQIDIIVCSDKSTFVQQILDYVTTEKVILYGVDPNSKYNENSKVYSYLVTPITHSKLISSILLSKNLKSKNSFLTTTNNTNNTNNTNNIENKSSIDSPLSITSTSSSIITPILTSNNLDLNNNNNNNNNSILVSNNGGVDGGNNVPSTLTTIQQSQPKKYILVAEDNDINIKVVVRQLEKLGYTAIVGINGLKALEIIGSFPICLILLDCQMPQMDGFTCSTILRQIEPTGQRIPIIAMTANDSKDRCFEVGMDDYLSKPVRVDRLQKTLSDWIKTDENGNPTNSYNFYPLSYSLVYNNFIDTQLKKEKNDD