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dnaN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Length
416 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
46.529 kDa
Sequence
MNFRLHGAFSNPSFVKIFFTKASPERRLTCFHVTKHGYSFQTDLHDYRKIMKFVISRNELGNLIKKVQNVVPQSTPIPVLTHVLIESCNDELVFTATDLTVSTRCVVKAKVYESGSVTIPSRRFFQLIRELTEANIEVAAHSGEMATITSGSSCFRLLSMGKEDFPMLPDMQNALRFTLDSERLKDMFQRTSFAVSREESRYVLTGVLLSIANGTMTVVGTDGKRLAKIDTEISLDPSFSGDYIIPIKAVEEIIRMSSEDVQSTIFLDQTKIAVECGNTLLVTKLLSGEFPDFSPVISTHSSVQLDLHREELISLLKQVALFTNESSHSVKFSFSPGELTLTANCTKVGEGKVSMAVNYTGETLEIAFNPFFFLDILKHSRDELVQLGISDSYNPGIITDSTRSLFVIMPMRLHDD

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
402 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.055 kDa
Sequence
MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVGVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
402 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.113 kDa
Sequence
MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
402 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication (By similarity). Binds ds-and ssDNA (PubMed:22545130). Binds the antibiotic griselimycin and its derivatives with high affinity (1.0 x 10(-10) to 2.0 x 10(-10) M s(-1)) (PubMed:26045430). Binding occurs in a hydrophobic cleft between domains 2 and 3, which have been shown to be responsible for binding DNA polymerases and other DNA-modifying proteins (PubMed:26045430).
Similarity
Belongs to the beta sliding clamp family.
Mass
42.113 kDa
Sequence
MDAATTRVGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTISGFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEAAKAGIGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALLRPVSGDDRPVAGLNGNGPFPAVSTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium leprae (strain TN)
Length
399 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.942 kDa
Sequence
MDLAKTNVGCSDLKFCLARESFASAVSWVAKYLPTRPTVPVLSGVLLTGSDSGLTISGFDYEVSAEVQVAAEIASSGSVLVSGRLLSDITRALPNKPVHFYVDGNRVALTCGSARFSLPTMAVEDYPTLPTLPDETGTLPSDVFAEAIGQVAIAAGRDYTLPMLTGIRIEISGDTVVLAATDRFRLAVRELKWSVLSSDFEASVLVPAKTLVEVAKAGTDGSGVCLSLGAGVGVGKDGLFGISGGGKRSTTRLLDAEFPKFRQLLPAEHTAVATIDVAELTEAIKLVALVADRGAQVRMEFGDGILRLSAGADDVGRAEEDLAVAFTGEPLTIAFNPNYLTDGLASVHSERVSFGFTTPSKPALLRPTSNDDVHPTHDGPFPALPTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Length
399 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.57 kDa
Sequence
MDAATTTAGLSDLKFRLVRESFADAVSWVAKSLPSRPAVPVLSGVLLSGTDEGLTISGFDYEVSAEAQVAAEIASPGSVLVSGRLLSDIVRALPNKPIDFYVDGNRVALNCGSARFSLPTMAVEDYPTLPTLPEETGTLPADLFAEAIGQVAIAAGRDDTLPMLTGIRVEISGDTVVLAATDRFRLAVRELTWSAASPDIEAAVLVPAKTLAEAARTGIDGSDVRLSLGAGAGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLLPAEHTAVATINVAELTEAIKLVALVADRGAQVRMEFSEGSLRLSAGADDVGRAEEDLAVDFAGEPLTIAFNPTYLTDGLGSVRSERVSFGFTTPGKPALLRPASDDDSPPSGSGPFSALPTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
397 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.325 kDa
Sequence
MATTTAGLTDLKFRVVREDFADAVAWVARSLPTRPTIPVLAGVLLTGTDEGLTISGFDYEVSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCGSARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRDDTLPMLTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAEAAKAGTDGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQLLPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADDVGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAVLRPAGEDDGANGGSGPFPAAKTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycobacterium smegmatis
Length
397 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.325 kDa
Sequence
MATTTAGLTDLKFRVVREDFADAVAWVARSLPTRPTIPVLAGVLLTGTDEGLTISGFDYEVSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCGSARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRDDTLPMLTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAEAAKAGTDGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQLLPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADDVGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAVLRPAGEDDGANGGSGPFPAAKTDYVYLLMPVRLPG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
391 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.088 kDa
Sequence
MKLICRQSDLSSGLSLVSRAVSSRPTHPVLGNVLLEADADKNYLRLTAFDLSLGIQSSFTADVQQSGRITLPAKLLNDIVSRLPDGDITLAIDPDGDAGDSHLTTITSESGRFQIRGLDADDFPALPTVEGVKPLLLPVATLNEGLRGALFAASTDETKQVLTGVHIKGSGDSLEFAATDGHRLAVVEAPTQIENDEGEAVITGSDLADFAVTIPARALRELERMVASQGNSDLVSLVVNDTQVIFELGDQRLTSRKLEGAYPAYDQLIPRQFSRTVTMERKRLITSLERVSVLADQKNNLVTFTLQSPGNQLQLAVEAQDLGHGEESMGAEIIGEGGQIAFNIKYLMDGLKALPSNDIQMQLNEGNQPVIFTPLGGLKMTYLVMPVRLVN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Length
385 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
44.641 kDa
Sequence
MLHNTFFICETNQIMNEIEKAKGIILNRNMNDIWSALLIEVKKSNLIIKSTDRNIFFESTISIVSETDFKVLINASNFYDAVKAFNFYKKIKIVFNENNSKLEIMGELNDEKEEYEDHLKEPTFSYEEIENYNYDMVNEDYTFGIEIKQKSFKKVINRIAFSAHLDESKNVLNGVYFSKDEDSKLLLVSTNGHRMSICKTEVIVEEDVNFIVPVKIFNFLKHLMSGEGMVKIKFSDKKFYVEFDNYKIACSLINGNYPDYKSIIPKEQKNKSLVSLGILKDRLARVNLYVDKSRKLVLTFSELQLKLLGEDLITGRKGEFFIKDPNYLYDGADEVMAINISYFVEAISVFETSKIEIQFNSGNVLKLSEPENFNFTHLIMPMSLG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Rickettsia prowazekii (strain Madrid E)
Length
381 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.969 kDa
Sequence
MLKLIVETKTLMQSLGFARSIIEKRNVIPEYANIKLSAQDGNLELSSTNMDLYLSQKIAVQVLNEGEITVATQTLSDIVRKFPDSELTLTEIEITQLEIKGQNCKFNLFTLPVSSFPAMDSIKPEVSFKISCADFAKIIESTKFSISLDETRYNLNGIYLHIKDKEFFAASTDGYRLSISWITLEEKIKNFGVILPQKSAEEILKIVKDPKNIHEDIEILLSSNKIKFICNENTILLSKLIDGTFPDYSAFIPKSSVSKLVINRKIFADSIERIAIITVEKFRAVKLSLSRKILEISAVGEARGTAKEIITASQDKESFYEYNHDESLVIGFNPQYLEDVLKAIKSDIVELYFSDISASAPVLIKFPRNPKDIFVIMPVKV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Length
381 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.822 kDa
Sequence
MLKLIVETKTLVQSLGFARSVVEKRNVIPEYANIKLSAKDGNLELSSTNMDLYLSQKIAVQVLSEGEITVSTQTLSDIVRKLPDSELTLTELDIMKLEIKGQNCQFNLFTLPVSSFPAMDSIKPEVSFKISCADFAKIIESTKFSISLDETRYNLNGIYLHIKDKEFFAASTDGHRLSISWITLEEKIKNFGVILPQKSAEEILKIVKDLKNIHEDIEILLSSNKIKFICNENTILLSKLIDGTFPDYSAFIPKSSISKLVINRKIFADSIERIAIITVEKFRAIKLSLSRKTLEISAVGEARGNAKEIITASQDKESFYEYNCDESLVIGFNPQYLEDVLKAVKSNLVELYFSDISASAPVLIKFPQNPKDIFVIMPVKV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
380 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
44.295 kDa
Sequence
MKILINKSELNKILKKMNNVIISNNKIKPHHSYFLIEAKEKEINFYANNEYFSVKCNLNKNIDILEQGSLIVKGKIFNDLINGIKEEIITIQEKDQTLLVKTKKTSINLNTINVNEFPRIRFNEKNDLSEFNQFKINYSLLVKGIKKIFHSVSNNREISSKFNGVNFNGSNGKEIFLEASDTYKLSVFEIKQETEPFDFILESNLLSFINSFNPEEDKSIVFYYRKDNKDSFSTEMLISMDNFMISYTSVNEKFPEVNYFFEFEPETKIVVQKNELKDALQRIQTLAQNERTFLCDMQINSSELKIRAIVNNIGNSLEEISCLKFEGYKLNISFNPSSLLDHIESFESNEINFDFQGNSKYFLITSKSEPELKQILVPSR

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
380 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
43.856 kDa
Sequence
MKVLINKNELNKILKKLNNVIVSNNKMKPYHSYLLIEATEKEINFYANNEYFSAKCTLAENIDVLEEGEVIVKGKIFSELINGIKEDIITIQEKDQTLLVKTKKTNINLNTIDKKEFPRIRFNQNVDLKEFDELKIQHSLLTKGLKKIAHAVSTFRESTRKFNGVNFNGSNGKQIFLEASDSYKLSVYEIKQKTDPFNFIVETNLLSFINSFNPEGGDLISIFFRKEHKDDLSTELLIKLDNFLINYTSINESFPRVMQLFDFEPETKVTIQKNELKDALQRILTLAQNERFFLCDMQVTNSHLKINSNVQNIGASLEEVTCLKFEGHKLNIAVNALSLLEHIDSFDTDEIELYFQGSNKYFLISSNNEPELKEILVPSK

Gene
dnaN
Protein
Beta sliding clamp
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
380 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.382 kDa
Sequence
MHFVIDRDIFVQNVNHVSKAVSSRTTIPILTGIKIVADHEGVTLTGSDSDISIETFIPLEEGDRQNVEVKQEGSIVLQAKVFAEIVKKLPEQEIEIHVQDSFVTTIRSGSSVFNLNGLDPDEYPRLPVLEEDHVFRLPQKILKDIIRQTVFAVSTQETRPVLTGVNFEIEDGILTCTATDSHRLAMRKVPVEKNDDELQFSNVVIPGKSLNELSKILDENEELLDIVVTENQTLFKLKNMLFFSRLLEGKYPVTKNMIPKEAKTSFAVHTKAFLQTLERALLLSREGKNQVINLKTLGDGVVEVTAITPEIGKVTENVATQGLEGEELRISFNGKNVIDALKVVDSESIHIAFTGAMSPFVLSPTDHDQSLHLFSPVRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Lactococcus lactis subsp. lactis (strain IL1403)
Length
380 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.264 kDa
Sequence
MIKFSINKNAFQNALRITKQAIGSKVTIPALTKLKIEVEENGITLIGSNGQISIKNFLPVDNKDASMLISGTGSVLLEAAFFENVVSQLPEVTLEFTEKEQKQVLLTSGKSEITLKGLDSEIYPHLQEISEGSSLKMKVKVLKEIFTETVFAVSTQENRPIFTGVHLETLSTGELKAVATDSHRMSQRLLPLEDSELKFDVILPSKSINSFKNVFTNDEEEIEIFISGSQMLFRNETISYYSRLIEGSYPDTNRLIPNEADYTLDLVFDAAQLRHTMDRARLLTVMTTNGTVKLTVSGDSVVTTANSPEVGSVHEELTALSKEGNDLAISFNPEYLIDALKVIKAPEVRIRFISNVRPFTLQPRNEESGFVQLITPVRTN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Length
380 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.209 kDa
Sequence
MIKFSINKTAFQNALKITKQAIGSKVTIPALTKLKIEVEEKGITLIGSNGQISIKNFLPADNKDASMLISGTGSVLLEAAFFENVVSQLPEVTLEFIEKEQKQVLLTSGKSEITLKGLDSEIYPHLQEISEGSSLKMKVKVLKEIFTETVFAVSTQENRPIFTGVHLETLSTGELKAVATDSHRMSQRLLPLEDTDLKFDVILPSKSINSFKNVFTNDEEEIEIFISGSQMLFQNETISYYSRLIEGSYPDTNRLIPNEADYTLDLVFDAAQLRHTMDRARLLTVMTTNGTVKLTVSGDSVVTTANSPEVGSVHEELTALSKEGNDLSISFNPEYLIDALKVIKAPEVRIRFISNVRPFTLQPRNEESGFVQLITPVRTN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Rickettsia bellii (strain RML369-C)
Length
379 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.849 kDa
Sequence
MLKVIVETKTLVQALGFASSVVEKRNIISELANIKLLAKDGLLELSSTNMDLYLSQKIGVQVVSEGELTVSTKTLNDIVKKLPDSELTLTDLGTTGLEITGKNCRFNLFTLPVESFPVMDNINPEASFKISCAEFAKIIESTKFSVSLDETRYNLNGIYLHVKDSEFYAASTDGHRLSVSSVVLAEKIEDFGVILPQKSAEEILKIVKDSKNANADIEILLSSNKIKFICNENVIMLSKLIDGTFPDYSSFIPENSSSKLVINRKIFADTIERIAIITVEKFRAVKLSLSGEALEISAIGEARGNAKEVINSSKETENFYEYSGETNLDIGFNPQYLEDVLKAIKSDLVELYFSSVSAPVLIKFPESPKDIFVVMPVKV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Length
379 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.237 kDa
Sequence
MLKLIVETKTLVQSLGFASSVVEKRNVIPEYANIKLSAKDGNLELSSTNMDLYLSQKIAVQVVSEGECTVSTKTLNDIVRKLPDSELTLTDLGTTGLEIKGKNCKFNLFTLPVSSFPAMDSINPEASFKISCTDFAKIIESTKFSISLDETRYNLNGVYLHIKDKEFCSASTDGHRLSISWVTLEKQIKNFGVILPQKSAEEILKIVKDPKNINEDIEILLSSNKIKFICNENTSMLSKLIDGTFPDYSTFIPESSSSKLVINRKMFADSIERIAIITVEKFRAVKLSLSRETLEISAVGEARGNAKEVINSSQDKESFYEYNSDESLAIGFNPQYLEDVLKAVKSDVVELYFSDVSAPVLIKFPENPKDIFVVMPVKV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Length
379 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.265 kDa
Sequence
MLKLIVETKTLVQSLGFASSVVEKRNVIPEYANIKLSAKDGNLELSSTNMDLYLSQKIAVQVVSEGELTVSTKTLNDIVRKLPDSELTLTDLGTTGLEIKGKNCKFNLFTLPVSSFPPMDSINPEASFKISCTDFAKIIESTKFSISLDETRYNLNGVYLHIKDKEFCSASTDGHRLSISWVTLEKQIKNFGVILPQKSAEEILKIVKDPKNINEDIEILLSSNKIKFICNENTIMLSKLIDGTFPDYSAFIPESSSSKLVINRKIFADSIERIAIITVEKFRAVKLSLSRETLEISAVGEARGNAKEVINSSQDKESFYEYNSDESLAIGFNPQYLEDVLKAVKSDLVELYFSDVSAPVLIKFPENPKDIFVVMPVKV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Length
378 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.073 kDa
Sequence
MIHFSINKNLFLQALNTTKRAISSKNAIPILSTVKIDVTNEGITLIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQNQIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRPILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDDIETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSMERARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYLIDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Length
378 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.071 kDa
Sequence
MIHFSINKNLFLQALNITKRAISSKNAIPILSTVKIDVTNEGVTLIGSNGQISIENFISQKNEDAGLLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQNQIVLTSGKSEITLKGKDSEQYPRIQEISASTPLILETKLLKKIINETAFAASTQESRPILTGVHFVLSQHKELKTVATDSHRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDDIETVEIFFANNQILFRSENISFYTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSMERARLLSSATQNGTVKLEIKDGVVSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYLIDSLKALNSEKVTISFISAVRPFTLVPADTDEDFMQLITPVRTN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Bacillus subtilis (strain 168)
Length
378 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.103 kDa
Sequence
MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSFTGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQYLTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRPILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDNQELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAIDRASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKYMLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus (strain COL)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus (strain N315)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus (strain MRSA252)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus (strain MSSA476)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus aureus (strain MW2)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.914 kDa
Sequence
MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.102 kDa
Sequence
MMEFTIKRDYFINQLNDTLKAISPRTTLPILTGIKIDAKENEVILTGSDSEISIEITIPKQVDGEEIVEITETGSVVLPGRFFVDIIKKLPGKEVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPEVSRDDAIQLSVKVLKNIIAQTNFAVSTSETRPVLTGVNWLIQDNELICTATDSHRLAVRKLQLEDESENKNVIIPGKALSELNKIMSDSDEDIDIFFASNQVLFRVGNINFISRLLEGHYPDTTRLFPENYEIKLGINNGDFYHAIDRASLLAREGGNNVIKLSTGNELVELSSTSPEIGTVKEEVNANDVEGGNLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKDDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
377 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.102 kDa
Sequence
MMEFTIKRDYFINQLNDTLKAISPRTTLPILTGIKIDAKENEVILTGSDSEISIEITIPKQVDGEEIVEITETGSVVLPGRFFVDIIKKLPGKEVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPEVSRDDAIQLSVKVLKNIIAQTNFAVSTSETRPVLTGVNWLIQDNELICTATDSHRLAVRKLQLEDESENKNVIIPGKALSELNKIMSDSDEDIDIFFASNQVLFRVGNINFISRLLEGHYPDTTRLFPENYEIKLGINNGDFYHAIDRASLLAREGGNNVIKLSTGNELVELSSTSPEIGTVKEEVNANDVEGGNLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKDDDSVTQLILPIRTY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
376 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
39.956 kDa
Sequence
MKIRVERDVLAEAVAWAARSLPARPPAPVLAGLLLKAEEGQLSLSSFDYEVSARVSVEAEIEEEGTVLVSGRLLADISRALPNRPVEISTDGVRATVVCGSSRFTLHTLPVEEYPALPQMPEATGTVPGEVFASAVQQVAIAAGRDDTLPVLTGVRIEIEGDSVTLASTDRYRFAVREFLWKPENPDISAVALVPAKTLQDTAKALTSGDQVILALSGSGAGEGLIGFEGAGRRTTTRLLEGDLPKYKTLFPTEFNSVAVIETAPFVEAVKRVALVAERNTPVRLSFEQGVLILEAGSSDDAQAVERVDAQLEGDDISIAFNPTFLLDGLSAIDSPVAQLSFTTSTKPALLSGRPAVDAEADEAYKYLIMPVRLSG

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Length
375 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.716 kDa
Sequence
MNFSINRIVLLDNLSKAAKVIDYKNVNPSLSGIYLNVLNDQVNVITTSGILSFKSILNNQNSDLEVKQEGKVLLKPKYVLEMLRRLDDEFVVFSMVEDNELIIKTNNSDFSIGVLNSEDYPLIGFREKGIEFNLNPKEVKKTIYQVFVSMNENNKKLILTGLNLKLNNNQAIFSTTDSFRISQKILEIQSDNNEDIDITIPFKTALELPKLLDNAENLKIIIVEGYITFIIDNVIFQSNLIDGKFPNVQIAFPTKFETIITVKQKSILKVLSRFDLVADDGLPAIVNIKVNEDKIEFKSFISEVGKYEEDFDDFVIEGNKSLSISFNTRFLIDAIKTLSEDRIELKLINSTKPIVINNVYDEHLKQVILPTFLSN

Gene
dnaN
Protein
Beta sliding clamp
Organism
Synechococcus elongatus (strain PCC 7942)
Length
375 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.466 kDa
Sequence
MKLVCRQNELNTSLSLVSRAVPSRPNHPVLANVLLAADAGTQRLSLTAFDLSLGIQTSFAAQVERSGAITLPAKLLNDIVSRLPNDSDVTLEDNDAAATLSVGSGQYQMRGISADEFPELPLVQSQEALQLSASALIEGLRGTLFATSGDETKQILTGVHLKVQPDGLEFAATDGHRLAVVKTENAAATPATEFAVTVPSRALRDLERMIAIRGSDEAIALYHDQGQTVFQWGDQYLTSRTLDGQYPNYGQLIPREFNRNVAVDRKRLLAALERIAVLADQQNNAIRLSLDPENNRLALAVDAQDVGSGQEAVPAEIIGEPLEIAFNVRYLAEGLKALNTTDIQIQLNSNTSPVVLSPLGPVKITYLVMPIQLRS

Gene
dnaN
Protein
Beta sliding clamp
Organism
Helicobacter pylori (strain J99 / ATCC 700824)
Length
374 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.047 kDa
Sequence
MKISVSKNDLENTLRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSDIGLKSYISTQSTDKEGVGTINGKKFLDIISCLKDSNIVLETKDDSLVIKQNKSSFKLPMFDADEFPEFPVIDPKVSLEINAPFLVDAFKKIAPVIEQTSHKRELAGVLMQFNQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALLEILKLFYENFSFKSDGMLAVVENETHAFFTKLIDGNYPDYQKILPKEYTSSFTLGKEEFKEGIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLKCNEPSSPFLIQEPLDEKQSHLNAKISTLMMPITL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Length
374 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.185 kDa
Sequence
MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSDIGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQNKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQTSHKRELAGILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALLEILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYISSFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLIQESLDEKQSHLNAKISTLMMPITL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Mycoplasma pulmonis (strain UAB CTIP)
Length
373 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.913 kDa
Sequence
MKLFLEKSRFLRFLENTTKIIESNNSNYELRGAYFQVRQDKIILISSNEDISIKNEYLLDGIKNKTEGESDFLVLNSLLKNIIKKCSDSIILEKEKNTLKIFSDLQSYEINLLDHERFPDIKFGLNNSQLQLKTEQFKQALKNVVFAADLSNAQELLLNSVNLSLKNNILTLVATNRARIAMQKIKTEDSQEFNLTINSKVVKELISLSMSNTLILSPGTFELKIKSGNLEIKTKVIEIPYMNVENVFPNKFNFVIHIDKKELLSLIDKVSIVNDEKNGNKILIEYNPSKKEKKLKLSSYWPDLGFSEVFSDNFEVESEILLKFFINANYLKESINVFDGMISIFITENKDRMVISSETNLNNKQLIAALRGH

Gene
dnaN
Protein
Beta sliding clamp
Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15)
Length
372 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.425 kDa
Sequence
MKLTIERAALLKALGHVQSVVERRNTIPILSNILLSAEGDRLSFSATDLDMEIIDEGFAQIDVPGQITAPAHTLYEIVRKLPDGADVSLSFSGDDPRLVIQAGRSRFNLPVLPAGDFPVMSSDGLSSRIAVDTNELIRLIDKTRFAISTEETRYYLNGLYVHTVNEGGETKLRAVATDGHRLALAEMPAPEGAVGIPGVIVPRKTIAEARRLMESAGETVDLQVSPQKVRFEFGAAALTSKVIDGAFPDYMRVIPRDNAKILTLDNDLFAKAVDRVATISAEKSRSVKLAVEPGRITLTVRNMEAGQAVEEVEVDYDGEPFEIGFNARYLLDVCGQIAGPQAEFRFADPASPTLVVDPVDPGVKYVLMPLRV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Caulobacter vibrioides (strain NA1000 / CB15N)
Length
372 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication (By similarity). Interaction with toxin SocB via the hydrophobic cleft blocks DNA replication elongation (PubMed:24239291).
Similarity
Belongs to the beta sliding clamp family.
Mass
40.425 kDa
Sequence
MKLTIERAALLKALGHVQSVVERRNTIPILSNILLSAEGDRLSFSATDLDMEIIDEGFAQIDVPGQITAPAHTLYEIVRKLPDGADVSLSFSGDDPRLVIQAGRSRFNLPVLPAGDFPVMSSDGLSSRIAVDTNELIRLIDKTRFAISTEETRYYLNGLYVHTVNEGGETKLRAVATDGHRLALAEMPAPEGAVGIPGVIVPRKTIAEARRLMESAGETVDLQVSPQKVRFEFGAAALTSKVIDGAFPDYMRVIPRDNAKILTLDNDLFAKAVDRVATISAEKSRSVKLAVEPGRITLTVRNMEAGQAVEEVEVDYDGEPFEIGFNARYLLDVCGQIAGPQAEFRFADPASPTLVVDPVDPGVKYVLMPLRV

Gene
dnaN
Protein
Beta sliding clamp
Organism
Treponema pallidum (strain Nichols)
Length
371 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.29 kDa
Sequence
MKILCEKEAFLKEISTAQEVISNKKNTSIFSNVLLAAQGALLTIRATDTKVTFETSIPVNVLAEGTTTVFCDKLVNVVSALPTKEIELTLCEEQLVITPPNKKISFQLRTLSHESFPCFPQNEGGVSLAVPTSDLRNMINHTVFAVSEDSTRHFINGVHVDFQYGNIICVSTDGKRLAYIEKKGESSPQSFSGVIVPTKILGIVNRKLTPEGSVTLCITSQHVYFFFGGYKFSSVLIEGQFPNYKRVIPDHQERSFCVGRVELMEALKRVSLLVEQKSHRIFITIQQGLLTLSSKAHTQENEIGDAQEEIACAYTGESEVIALNYLYLEEPLKVFTSKEVQVEFTDPAKALTLRAVPNTDCFHIIMPMQTE

Gene
dnaN
Protein
Beta sliding clamp
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
371 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.72 kDa
Sequence
MKFEILNKFLIKSLKKVNNLITRNHIFPILENILLIAKDNTITLTSTNIDMEIKIIILDVTLLEPGSITVSGKKILNICQNLPKDHNLKIQYINNKLKIVSHNNQYLLATLPIKNFPNLKISENQNNFVISQNDLKDVLCATYFSMAIQDLRNFLNGLFFEVRNQHLYAVATDGYRIAICKKPLHNLDKKKYNSIILPRKGVLELIKLLNYSNEVISINISNNYFQIEFKNLIFTSKIITEKFPDYTSLILTHISKKMILNTTLFKEALSRVAILSNENFRGVNIKNDQNKLLITTSNQHDEEASEIIDIIYTNIKIKMSINASYMIDILNAIQDQEICLSKNDVTHSIQIQAHHYKIAPKAIYIIMPLYA

Gene
dnaN
Protein
Beta sliding clamp
Organism
Proteus mirabilis
Length
367 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.748 kDa
Sequence
MKFIIEREQLLKPLQQVSGPLGGRPTLPILGNLLLKVTENTLSLTGTDLEMEMMARVSLSQSHEIGATTVPARKFFDIWRGLPEGAEISVELDGDRLLVRSGRSRFSLSTLPASDFPNLDDWQSEVEFTLPQATLKRLIESTQFSMAHQDVRYYLNGMLFETENTELRTVATDGHRLAVCAMDIGQSLPGHSVIVPRKGVIELMRLLDGSGESLLQLQIGSNNLRAHVGDFIFTSKLVDGRFPDYRRVLPKNPTKTVIAGCDILKQAFSRAAILSNEKFRGVRINLTNGQLKITANNPEQEEAEEIVDVQYQGEEMEIGFNVSYLLDVLNTLKCEEVKLLLTDAVSSVQVENVASAAAAYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
367 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.694 kDa
Sequence
MHFTIQREALLKPLQLVAGVVERRQTLPVLSNVLLVVEGQQLSLTGTDLEVELVGRVVLEDAAEPGEITVPARKLMDICKSLPNDVLIDIRVEEQKLLVKAGRSRFTLSTLPANDFPTVEEGPGSLNFSIAQSKLRRLIDRTSFAMAQQDVRYYLNGMLLEVNGGTLRSVATDGHRLAMCSLDAQIPSQDRHQVIVPRKGILELARLLTEQDGEVGIVLGQHHIRATTGEFTFTSKLVDGKFPDYERVLPRGGDKLVVGDRQQLREAFSRTAILSNEKYRGIRLQLSNGLLKIQANNPEQEEAEEEVQVEYNGGNLEIGFNVSYLLDVLGVIGTEQVRFILSDSNSSALVHEADNDDSAYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
367 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.719 kDa
Sequence
MHFTIQREALLKPLQLVAGVVERRQTLPVLSNVLLVVQGQQLSLTGTDLEVELVGRVQLEEPAEPGEITVPARKLMDICKSLPNDALIDIKVDEQKLLVKAGRSRFTLSTLPANDFPTVEEGPGSLTCNLEQSKLRRLIERTSFAMAQQDVRYYLNGMLLEVSRNTLRAVSTDGHRLALCSMSAPIEQEDRHQVIVPRKGILELARLLTDPEGMVSIVLGQHHIRATTGEFTFTSKLVDGKFPDYERVLPKGGDKLVVGDRQALREAFSRTAILSNEKYRGIRLQLAAGQLKIQANNPEQEEAEEEISVDYEGSSLEIGFNVSYLLDVLGVMTTEQVRLILSDSNSSALLQEAGNDDSSYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Pseudomonas putida
Length
367 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.719 kDa
Sequence
MHFTIQREALLKPLQLVAGVVERRQTLPVLSNVLLVVQGQQLSLTGTDLEVELVGRVQLEEPAEPGEITVPARKLMDICKSLPNDALIDIKVDEQKLLVKAGRSRFTLSTLPANDFPTVEEGPGSLTCNLEQSKLRRLIERTSFAMAQQDVRYYLNGMLLEVSRNTLRAVSTDGHRLALCSMSAPIEQEDRHQVIVPRKGILELARLLTDPEGMVSIVLGQHHIRATTGEFTFTSKLVDGKFPDYERVLPKGGDKLVVGDRQALREAFSRTAILSNEKYRGIRLQLAAGQLKIQANNPEQEEAEEEISVDYEGSSLEIGFNVSYLLDVLGVMTTEQVRLILSDSNSSALLQEAGNDDSSYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.642 kDa
Sequence
MKFTIERSHLIKPLQQVSGTLGGRASLPILGNLLLKVEENQLSMTATDLEVELISRVTLEGEFEAGSITVPARKFLDICRGLPDSAVITVLLEGDRIQVRSGRSRFSLATLPASDFPNIEDWQSEVQVSLTQAELRGLIEKTQFSMANQDVRYYLNGMLFEIDGTTLRSVATDGHRMAVAQAQLGADFAQKQIIVPRKGVLELVKLLDAPEQPVVLQIGHSNLRAEVNHFVFTSKLVDGRFPDYRRVLPQHTSKTLQTGCEELRQAFSRAAILSNEKFRGVRVNLADNGMRITANNPEQEEAEELLDVSFEGEPIEIGFNVSYILDVLNTLRCDNVRVSMSDANASALVENVDDDSAMYVVMPIRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.548 kDa
Sequence
MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVTLSQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGDRMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIESTQFSMAHQDVRYYLNGMLFETEGSELRTVATDGHRLAVCSMPLEASLPSHSVIVPRKGVIELMRMLDGGENPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDILKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVSYGGTEMEIGFNVSYVLDVLNALKCETVRIMLTDSVSSVQIEDAASQSAAYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.985 kDa
Sequence
MKFIINNNILIKNLQKISRLLVKNTSLPILDNVLINIKNGMLSLTGTNLEIELVAMIQLSTEHISGTATISGRKLLDICRNSLNSSNIEMQLNNNKMHIISGNSRYILTTLPYDSFPVHHDFHHISEFFIPSDILKKMIEKIQFSMAKQDVRYYLNGILLEKTDRSLYAVATDGYRLGISKFFLKENIIPFSIVIPRKGVIELYRLLNIPKQPIKVLVGKNNIRVHIEDLIFTTQLIEGQYPDYKSVLLENKNNFITLNSKLLKQSLLRAAILSHEKFCGVEIHIRNGQFKVLSDNQEEEIAEDRFNINYTGNTVKISINVYYIIEILNSITSENIFLFLNNANNSIQIEAENDASILYVVMLLKR

Gene
dnaN
Protein
Beta sliding clamp
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.18 kDa
Sequence
MKFTIQNDILTKNLKKITRVLVKNISFPILENILIQVEDGTLSLTTTNLEIELISKIEIITKYIPGKTTISGRKILNICRTLSEKSKIKMQLKNKKMYISSENSNYILSTLSADTFPNHQNFDYISKFDISSNILKEMIEKTEFSMGKQDVRYYLNGMLLEKKDKFLRSVATDGYRLAISYTQLKKDINFFSIIIPNKAVMELLKLLNTQPQLLNILIGSNSIRIYTKNLIFTTQLIEGEYPDYKSVLFKEKKNPIITNSILLKKSLLRVAILAHEKFCGIEIKIENGKFKVLSDNQEEETAEDLFEIDYFGEKIEISINVYYLLDVINNIKSENIALFLNKSKSSIQIEAENNSSNAYVVMLLKR

Gene
dnaN
Protein
Beta sliding clamp
Organism
Buchnera aphidicola subsp. Rhopalosiphum padi
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
42.185 kDa
Sequence
MKFTIQNDILVENLKKITRLLIKNVSFPILENILIQIENGILSLTTTNLEIELVSKIKIITKYTPGKITISGRKILNICRNLSEKSEVKMPLKEKKMYVSCENSNYILSTLSADDFPNHQNFNHISNFHISSNILKEMIEKTEFSMGKQDVRYYLNGMLLEKKDNFLRSVATDGYRLAISYSKLEKDINFFSIIIPSKAVMELSRLLNTQVQLLNILIGTNSIRIYIKDLIFTTQLIEGEYPDYESVLFKEKKNPIIANCTLLKKSLLRAAILAHEKFCGIEIKIEKNKFKVLSDNQEEETAEDLFDINYLGDTIEISINVYYLLDVINNIKSENIILFLNKSKSSIQIEAENNSLNAYIIMLLKR

Gene
dnaN
Protein
Beta sliding clamp
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.493 kDa
Sequence
MKFVISRNELGNLIKKVQNVVPQSTPIPVLTHVLIESCNDELVFTATDLTVSTRCVVKAKVYESGSVTIPSRRFFQLIRELTEANIEVAANSGEMATITSGSSCFRLLSMGKEDFPMLPDMQNALRFTLDSEQLKDMFQRTSFAVSREESRYVLTGVLLSISNGTMTVVGTDGKRLAKIDTNISLDPSFSGDYIIPIKAVEEIIRMASEDVQSTIFLDQTKIAVECGNTLLVTKLLSGEFPDFSPVISTQSSVQLNLHREELISLLKQVALFTNESSHSVKFSFSPGELTLTANCTKVGEGKVSMAVNYTGETLEIAFNPFFFLDILKHSRDELVQLGISDSYNPGIITDSTRSLFVIMPMRLHDD

Gene
dnaN
Protein
Beta sliding clamp
Organism
Chlamydia pneumoniae
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.365 kDa
Sequence
MKFVVSRNELGNLIKKIQSVVPQNTPIPVLTHVLIETYNDELVFTATDLTVSTRCVTKAKVYEKGAISIPSKRFFQLVKELTEANLEISSSAGEMAQITSGSSCFRLLSMEKEDFPMLPDIQNALRFSLPAEQLKTMLQRTSFAVSREESRYVLTGVLLAIANGVATIVGTDGKRLAKIDAEVTLDKSFSGEYIIPIKAVEEIIKMCSDEGEATIFLDQDKIAVECDNTLLITKLLSGEFPDFSPVISTESNVKLDLHREELITLLKQVALFTNESSHSVKFSFLPGELTLTANCTKVGEGKVSMAVNYSGELLEIAFNPFFFLDILKHSKDELVSLGISDSYNPGIITDSASGLFVIMPMRLHDD

Gene
dnaN
Protein
Beta sliding clamp
Organism
Escherichia coli O157:H7
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.587 kDa
Sequence
MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
40.587 kDa
Sequence
MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Escherichia coli (strain K12)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA (PubMed:2040637). DNA bound in the ring is bent 22 degrees, in solution primed DNA is bound more tightly than dsDNA, suggesting the clamp binds both ss- and dsDNA (PubMed:18191219). In a complex of DNA with this protein, alpha, epsilon and tau subunits however the DNA is only slightly bent (PubMed:26499492). Coordinates protein traffic at the replication fork, where it interacts with multiple DNA polymerases, repair factors and other proteins (PubMed:15466025, PubMed:16168375, PubMed:22716942, PubMed:14592985, PubMed:14729336, PubMed:26499492, PubMed:15952889). Initially characterized for its ability to contact the alpha subunit (dnaE) of DNA polymerase III (Pol III), tethering it to the DNA and conferring very high processivity (PubMed:2040637). Pol III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; it also exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication (PubMed:3519609, PubMed:2040637). A single clamp can bind both Pol III and IV, allowing the repair Pol IV to access DNA when it is damaged and needs to be fixed, a process the replicative polymerase cannot perform; when DNA is repaired Pol III takes over again (PubMed:16168375). Serves as a processivity factor for DNA polymerases II (PubMed:1999435, PubMed:1534562), IV (PubMed:10801133) and V (PubMed:10801133). A shorter protein beta* may be important for increasing survival after UV irradiation, and stimulates DNA synthesis with increased processivity in the presence of core Pol III plus the clamp loader complex (PubMed:8576210, PubMed:8576212).
Similarity
Belongs to the beta sliding clamp family.
Mass
40.587 kDa
Sequence
MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
366 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.631 kDa
Sequence
MQFSISRENLLKPLQQVCGVLSNRPNIPVLNNVLLQIEDYRLTITGTDLEVELSSQTQLSSSSENGTFTIPAKKFLDICRTLSDDSEITVTFEQDRALVQSGRSRFTLATQPAEEYPNLTDWQSEVDFELPQNTLRRLIEATQFSMANQDARYFLNGMKFETEGNLLRTVATDGHRLAVCTISLEQELQNHSVILPRKGVLELVRLLETNDEPARLQIGTNNLRVHLKNTVFTSKLIDGRFPDYRRVLPRNATKIVEGNWEMLKQAFARASILSNERARSVRLSLKENQLKITASNTEHEEAEEIVDVNYNGEELEVGFNVTYILDVLNALKCNQVRMCLTDAFSSCLIENCEDSSCEYVIMPMRL

Gene
dnaN
Protein
Beta sliding clamp
Organism
Spiroplasma citri
Length
363 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
41.329 kDa
Sequence
MIVNIKRDKILDELLKVSRIISQKTLIPSLLGILIEVKKDKITFTTSDGDTSIKSEIMGNDLNITRIGSVLIKNKFIVEVIRKIEDEFITLEVVEGNLIKIKANNFDSVLNTLNSADYPHLSFETEGKEIIFTSTVLKEIISQTSFAIGEKEKRIVFNGLNIKTDQNNKELIITATDSFRLSCKKIDYSNNYNFDVIIPGKFINEIGRLISENDQVSELLLIIINCKQKIIEGKYPDTSKVIRTSFNTSLTINNRAIIKIIERRSVLSNETMTTIVTLKIKEQKVLVTSFTQEIGNTEEEIRDFKVEGTDQIIAFNSKYILDALKAFKTKEITIKMIDERKPLIITANDDQTLQQLVLPIRSY

Gene
dnaN
Protein
Beta sliding clamp
Organism
Micrococcus luteus
Length
310 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
32.624 kDa
Fragment
single
Sequence
MKFTVERDILTDAVSWAARSLSPRPPVPVLSGLLITAEAGVVSIASFDYETSARLEIEADVETAGQVLVSGRLLNDIVRSLPQAQVTVELDGGKVLVTCRSSRFSLATMPVGDYPALPELPAPAGTVDGAAFAHAVAQVTVAASKDDTLPILTAVKVEIEGDTITFLATDRYRLAMKEIRWTPADPSISTSLLIKARTLTEVAKSLGSGGDLEILLGQTADLVGFASGGRRTTSVLVDGEYPKIRSLFPESSPIQAVVDTAALVEASRRVALVAERNTALRMVFTEGQVTLDAGTGDDASANESVPCTLE

Gene
dnaN
Protein
Beta sliding clamp
Organism
Vibrio harveyi
Length
145 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
16.059 kDa
Fragment
single
Sequence
MKFTIERSHLIKPLQQVSGALGGRPTLPILGNLLLKVEDNVLSMTATDLEVELVSKVTLEGDFEAGSITVPSRKFLDICRGLPDDSIITFVLEGDRVQVRSGRSRFSLATLPANDFPNIEDWQSEVEVSLTQSDLRTLIEKTQFS

Gene
dnaN
Protein
Beta sliding clamp
Organism
Serratia marcescens
Length
78 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
8.548 kDa
Fragment
single
Sequence
MKFIVEREHLLKPLQQVSSPLGGRPTLPILGNLLLQVTEGSLLLTGTDLEMEMVARVALSQPHEPGATTVPARKFFDI

Gene
dnaN
Protein
Beta sliding clamp
Organism
Rhodobacter capsulatus
Length
70 amino acids
Function
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
Similarity
Belongs to the beta sliding clamp family.
Mass
7.547 kDa
Fragment
single
Sequence
MWRPAKXPALRCVATDGHRLARIDAVLPEGANGMPGVIVPRKTVNELRNVLDDDEAQIAVSVSETRCALA