Protein
Des-methyl DIF-1 methyltransferase A
Organism
Dictyostelium discoideum
Function
Catalyzes the last step of DIF-1 biosynthesis (methylation of dichloro-THPH or des-methyl-DIF-1). DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Sequence
MISNSDCDENLIKQQQQEIQDKNFLIDVAIGYTKSNALSCALKYKIPQLLEDKSKSCKELSEILKVNCDNLYRLLRTLSTIGIFIEDEVEDGVFRNSRLSNLLRNSNSDSWVNNVYLQSHPNVIQSFMYLDKTIECGTSQGMTSQGFSSAWELFEKDKSLNAHFHNTMTSFTSDEIKTILEYIDFNQYKSIVDLGGSSGELLKSIAKSSRGQLVESFINFDLPLVINQNKVNNENGAAEFDKRYSEVASDLFVDSDYPSADCYTLKFIFHMFNDDKVLTILDKISKSIKPNGKVYVFDHIVQPKNQPYAPFYFDLQMIVNFNGKERSQNEWKTIFEKSPFKIDTILILPDSKRMSVIELSLKQ