DISP1

Protein dispatched homolog 1

1524 amino acids

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).

Belongs to the dispatched family.

170.934 kDa

MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNGTVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHTVCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQAVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRSIEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVELSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPNMEANVPAVLTHSELSGESLLIKTL

Disp1

Protein dispatched homolog 1

1521 amino acids

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).

Belongs to the dispatched family.

170.13 kDa

MAVISGSDSVLLSNGSISTSTSNPSPLSPSDGDLPAQHLGPRETPRTKASPNGCLQLNGTVKSSFLPLDNQRTPQTPTQCCHPCPYHHPVSSHSNHQECHPEAGLAASPALASCRMQPHSEYSASLCPNHSPVYQAAHCLQPSPSFCLHHPWPDHFQHQPVRQHLTIIRPSRPFKFPRSYAALLADWPVVVLGMCTLLIVVCALVGVLVPELPDFSDPLLGFEPRGTTIGQRLVTWNNMMRNTGYKATLANYPYKYAEEQARSHRDDRWSDDHHERERREVDWNFQKDSFFCDVPSDGYSRVVFASAGGETLWNLPAIKSMCDVDNSRIRSHPQFSDLCQRTTAVSCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDKAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGITTVTGIEFGIKHSLFQDYLLMDTVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERYLLNIFTCFRKPQPQAYDKSCWAVLCQKCRRVLFAVSEASRIFFEKVLPCIVIKFRYLWLIWFLALTVGGAYIVCVNPKMKLPSLELSEFQVFRSSHPFERYDAEFKKLFMFERVHHGEELHMPITVIWGVSPEDSGDPLNPKSKGELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQWMENQDCDEPALYPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTPGPRFDINDTIRAVVLEFQSTFLFTLAYEKMQQFYKEVDSWISHELSSAPEGLSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQIPFPTKLQCSPFSHTLSARPGDRGPSKTHAASAYSVDARGQKSQLEHEFYELQPLASHSCTSSEKTTYEEPHTCSEFFNGQAKNLRMPVPAAYSSELTKSPSSEPGSALLQSCLEQDTVCHFSLNPRCNCRDAYTHLQYGLPEIHCQQMGDSLCHKCASTAGGFVQIQSSVAPLKASHQAAEGLLHPAQHMLPPGMQNSRPRNFFLHSVQHFQAQENLGRTSTHSTDERLPRTAELSPPPSDSRSTESFQRACCHPENNQRRLCKSRDPGDTEGSGGTKSKVSGLPNQTDKEEKQVEPSLLQTDETVNSEHLNHNESNFTFSHLPGEAGCRSCPNSPQSCRSIMRSKCGTEDCQTPNLEANVPAVPTHSDLSGESLLIKTL

disp1

Protein dispatched homolog 1

1464 amino acids

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (PubMed:15110707). Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity).

Belongs to the dispatched family.

164.535 kDa

MALSEDFTELQTLSNGRSSSIFPTTNTPVDPEEEEEQSVSACTQPNEHTQMMQTGQNGGLKSTRLSSSSSSSSQLTDAQRLAVLLPNALPPGFCVCCSLCCNGNQQDCALFQSAVPSAALHMGSCCVQGVPCFCMQHHWPEHLQNQPNMATLSPPRPFRFPKNYAELIADWPVVVLGICTVLIVVCALVGILVPDLPDFSNPLQGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHQDDRWSKDHYDRKKRQAEWDFSKDSFFCDVPGDSYSRIVFASAEGKNLWNIQAIKSMCNFDNTRVRSHPQYLDLCQRTTAASCCPSWTLGNYIAVLTNKSSCQKITERDVSHTLNILRSCAKFYHNGTLGPECWDMTTRKKDLKCGNLPRKCTKYNAVYQIFHFLVDKDFLNPKNTDYLPPNLKYSMLFAPTEKGETMMNIYLDNFENRNSSDGITTITGIEFGIKHSLFQDYLLTDTMYPAIAIVIVLVVMCVYTRSMFITLMTMFAIISSLIVSYFLYRVVFNFDFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPNSELSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYILMVTWLPAVVVLHERYLVNLLTCSRTQNHQSQGAATFWTSLCQVVNKCLFSISEASRIFFEKVLPCVVIKLRYLWLLWFLALTVGGAYVVCVNPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVNHGEDLHMPITIIWGVTPIDSGDPLNPKNKGKLTLDTTFNIASPASQVWILNFCQKLRNQSFVYQSEEQDFTSCFMETFKQWMENQDCEEASVYPCCSQSTFPYRQDVFELCIKRAIMELDRSTIYHLDSKTPGPRFDINDTIRAIVLEFQSTYHFTLAYEKMHQFYREVDTWIQEELRDAPEGLSYGWFVSNLEFYDLQDSLSDGTLIAMALSVVVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPEPDREGKVVFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFLMLIMCISWAFATFFFQCMCRLLGPQGTCGQIPLPKKLQCAERTSENQSTVNNQGKAGACYTTKHEHYELEPLAANVRNEGKASDEEQEACTQLQNNITSLHDDATLCASHEEPKHEFENGVQATEHSHLHQYAFNTRCTCENSMHQYIRERQRTACHPCGQSRETQCATKQSNHLPVCLNRDMIHAPTNSGHFQHCTPSQISRPAAHRCFSGGCGMHAVHISQQQTETESYISACVPSSSPQESQNRPAHLQFPDVQRCSSPDTTGVCTLNHDTQNAGELAINSQSPQKIPWNHLKTKANGTCVLQDCREVVPEDSIGCRVDKEKTVSPKKFNCFKKNVNAKCNSVEFHKTRTSVPTIAINSKASSESLC