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disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Length
374 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.021 kDa
Sequence
MAANDRAAAPGKSGGSSGADGLMRASLSAVAPGTALRDGLERILRGNTGGLIVLGSDKTVEAMCTGGFVLDVEFTATRLRELCKLDGGIVLSSDLSKILRAGVQLVPDPMIPTEETGTRHRTADRVSKQVGFPVVSVSQSMRLVALYVDGMRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVSAVAQRLEMVRRIATEIAEYVVELGTDGRLLALQLDELIAGVEPERELVVRDYVPEPTAKRSRTVDQALYELDALTHAELLELATVAKALGYTGSPEALDSAVSPRGFRLLAKVPRLPGAIIDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
374 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.044 kDa
Sequence
MAANDRAAAPGKSGGSAGADGLMRASLSAVAPGTSLRDGLERVLRGNTGGLIVLGSDKTVESMCTGGFVLDVEFTATRLRELCKLDGGIVLSSDLSKILRAGVQLLPDPTIPTEETGTRHRTADRVSKQVGFPVVSVSQSMRLIALYVDGQRRVLEDSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVSAVAQRLEMVRRIATEIAEYVVELGTDGRLLALQLDELIAGVEPERELVVRDYVPEPTAKRSRTVDEALAELDKLSHAELLELSTVARALGYTGSPETLDSAVSPRGFRLLAKVPRLPGAIIDRLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Length
374 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.408 kDa
Sequence
MAANDRATTPGKSGQGTGNEALMRASLSAVAPGMALRDGLERILRGNTGGLIVLGMDKTVESMCTGGFVLDVEFTATRLRELCKLDGALILDKDMTKILRAGVQLVPDASIHTEETGTRHRTADRVSKACGFPVVSVSQSMRLIALYVDGERRVLEESSAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERELVVRDYVPEPTAKRSRTVAEALTELDALSHTELLELPVVARALGYSGSPETLDSAVSPRGFRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
372 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
40.512 kDa
Sequence
MAVKSGARSGRNVVHLARPTLRETLGRLAPGTPLRDGLERILRGRTGALIVLGYDDSVEAICDGGFVLDVRYAPTRLRELSKMDGAVVLSSDGSRILRANVQLVPDPSIPTDESGTRHRSAERTAIQTGYPVISVSHSMSIVTVYVAGERHVVPDSATILSRANQTIATLERYKGRLDEVSRQLSTAEIEDFVTLRDVMTVVQRLEMVRRISLEIDADVVELGTDGRQLKLQLDELVGDNETARELIVRDYHANPDPPTAAQVAATLEELDSLSDSELLDFTVLARVFGYPSTAEAQDSAMSSRGYRAMAAIPRLQFAHVDLLVRSFGSLQNLLAASADDLQSVDGIGSMWARHIREGLSLLAESTIADRLA
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length
368 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
40.18 kDa
Sequence
MAANDRPDRSDRGADERLRATLAAIAPGTQMRDALERILRGNTGALIVLGYDKTVESICSGGFNLDVELSAPLMRELAKMDGAIILDEKATRIIKANVHLQPDPSIPTNESGTRHRSAERTARQTGFPVISVSQSMRIIALYVDGRRHVLDEPSAILSRANQALATLERYKLRLDEVSGTLSALEIEDLVTVRDAAVVAQRLEMVRRIADEIQGYVVELGTDGRLLSLQLDELLAGVEPERDLIVRDYLPAAAGKRGRSVDDVLRDLDALTPEELLDLGTVARVIGCGGTENLDNPVSPRGYRLLAKIPRLPCAVIERLVEHFGTLQKLLAASVDDLQAVEGVGESRARSVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Corynebacterium glutamicum (strain R)
Length
366 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
40.259 kDa
Sequence
MTPTTTPVSNPDALAPGTQDVHTLKGTLQRLAPGTPLRDSLDRIVRGHTGALIVIGDDENVTSICDGGFEFDVPFAATRLRELCKMDGAVILSSDIERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTITLYVEGKAHMLEQPSTLLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKQIQIQLSELRGDNDRERESIIADYLVTDGIPADEEIYAALEAISHLDDKALLKPANIARILGLPPTEEALDEPVAPRGYRTLNRIPRVQKFLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
366 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
40.171 kDa
Sequence
MTPTTTPVSNPDALSTGTQDVHTLKGTLQRLAPGTPLRDGLDRIVRGHTGALIVIGDDENVSSICDGGFEFDVSFAATRLRELCKMDGAVILSSDLERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTITLYVEGKSHMLEQPAALLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKEIQIQLSELRGDNDRERESIIADYLVTDGIPADEEIHAALEAISHLDDKALLNPANIARVLGLPPTEEALDEPVTPRGYRTLNRIPRVQKFLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus subtilis (strain 168)
Length
360 amino acids
Function
One of 3 paralogous diadenylate cyclases (DAC) in this bacteria (PubMed:23192352). Has diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:18439896, PubMed:25616256). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. Does not convert GTP to c-di-GMP (PubMed:18439896).
Similarity
Belongs to the DisA family.
Mass
40.734 kDa
Sequence
MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIVVGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATISSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAIQTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTEGHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKLLGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEGIGEVRAQKIKKGLKRLQEKHYLDRQL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium tetani (strain Massachusetts / E88)
Length
360 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
41.098 kDa
Sequence
MIKVRLQKDNDLMDILNIMAPGTPLRDGLENILRAKTGGLIVIGDSEEILDIVDGGFTIDAEYSPSYVYELAKMDGAIILSGDVKRIIRANAQLMPDPSVPTFETGTRHRTADRIAKQTGNIVIAISQRRNIITIYRNNIKYVLRDSSVILGKANQALQTLEKYVSVLDKVINNLNVLEFRDLVTLFDVMTAIQRTEMVMRIVWEMERYICELGNEARLISMQLNELVRYVEEDEILLIRDYCETYMDYTEVYDEIQSMSSEELINLDQISKILGYTGVPLVDTFISPRGYRMLHRIPRIPSNVIENVVKNFKELKAVMEASYEQLDKVEGIGEARAKAIKNGLRRLKEQANIDKNIVTR
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
Length
360 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.518 kDa
Sequence
MTGLDRKKDDEIIEVLRMMAPGTSLREGLDNILLARTGALIVIGDSEKVLSLVDGGFYINKDYTPAHIYELAKMDGAIILSKDLKKILYANALLVPDTSIPTAETGTRHKTADRVAKQTGEVVVSISQRRNIITIYMGSRKYILRETPVILAEANQALQTLEKYKVALVEAINNLNILEIEDIVTLDDVAFVLQRTEMLMRVAAEIERYISELGSEGRLISLQLDELLTNVDADELFIIEDYAIRTDLRSDEILEKLRQLSYDELMNLVNICSILGYSPNADAFEMVISPRGYRLLSKIPRVPVNIIRNLVKKFSNLQGILNASIEELDDVAGIGEVRARIIWDGLRRVQEQIFLDSRKL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus pumilus (strain SAFR-032)
Length
359 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.736 kDa
Sequence
MEKEKKGARELDLLDIVQFVAPGTPLRAGIENVLRANTGGLIVVGYNDKVKSVVDGGFHINSAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATIHSSETGMRHRTAERVAKQTGCLIIAISERRNVITLYQGNRRYTLKDIGFILTKANQAIQTLEKYKTILDHAISALSALEFEELVTFGDVLSVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVNELITDMEQEAALFIKDYVKEKIKDPYVLLKQLQDMSSFELLDDSILYKLLGYPASTNIDEYVYTRGYRLLHKIPRLPMPIVENVVEAFGVLDRIMEADVQDLDEVEGIGEVRAKKIKKGLKRLQEKHYIDRQL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)
Length
359 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
38.571 kDa
Sequence
MSELVADPTGRAVLRAVAPGTELRDGLERILRGRTGALIVLGYDEVVEEMCSGGFVLDVAFSATRLRELAKMDGAIVLDRGATRVLRAAVQLLPDAAIETGESGTRHRTAERAAKQTGFPVISVSQSMRIVAIYSDGRRWVLEDSDAILSRANQALATLERYKSRLDEVSGTLSALEIEDLVTVRDVASVVQRLEMVRRISVEIAGYVDELGTDGRLLSLQLDELIGNVGPERELVVSDYVDARRAAALDDVLAGLARLDSTDLIDLVKIAQVRGLGGPGGDALDSAVGPRGHRMLSKIPRLPSPVIGAMVDHFGTLQKMLSASVEDLQLVDGVGALRARSVREGLSRLAESSLLERFV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Frankia alni (strain ACN14a)
Length
359 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
38.885 kDa
Sequence
MAGPPGDDIFRATLAAVAPGTPFRDGLERILRGHTGALIVLGHDKVVEGLCTGGFELDVEFSATRLRELAKMDGAIVLSSDLQRIVRAAVHLVPDPTVPTEESGTRHRTAERVAKQTEYPVISVSQSMHIIALYVAGRRYVLDGSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAISVSQRLEMVRRIADEIEGYVVELGTDGRLLSLQLEELMAGVETERELTVRDYLPAGSKAGSAAQVLSELSAMSPTDLLDLTVLARVIGFSGGADILDRQISPRGYRMLAKVPRLPRMVVDRLVDHFGTLQKLLAAGVDDLQAVDGVGETRARAVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Length
359 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
38.891 kDa
Sequence
MAGPPGDDIFRATLAAVAPGTPFRDGLERILRGHTGALIVLGHDKVVEGLCTGGFELDVEFSATRLRELAKMDGAIVLSSDLQRIVRAAVHLVPDPTVPTEESGTRHRTAERVAKQAEFPVISVSQSMHIIALYVAGRRYVLDGSAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAISVSQRLEMVRRIADEIEGYVVELGTDGRLLSLQLEELMAGVETERELTVRDYLPIGSKAGTPAQVLGELSAMSPTDLLDLTVLARVIGFSGGADILDRQISPRGYRMLAKVPRLPRMVVDRLVDHFGTLQKLLAAGVDDLQAVDGVGETRARAVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Frankia sp. (strain EAN1pec)
Length
359 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
38.851 kDa
Sequence
MAGPPGDDIFRATLAAVAPGTPFRDGLERILRGHTGALIVLGHDKVVEGLCTGGFELDVEFSATRLRELAKMDGAIVLSSDLARIVRAAVHLVPDPTVPTEESGTRHRTAERVAKQTGFPVISVSQSMHIIALYVAGRRYVLDGAAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDAISVSQRLEMVRRIADEIESYVVELGTDGRLLSLQLEELMAGVETERELTVRDYLPVGSRAGNAAQVLAELSAMSPTDLLDLTVIARVIGFSGGADILDRQISPRGYRMLAKVPRLPRMVVDRLVDHFSTLQKLLAAGVDDLQAVDGVGETRARAVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Length
359 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
39.093 kDa
Sequence
MPDRTPDEVLRQTLAILAPGTDLRDGLERILRGRTGALIVLGFDRVVDSLSTGGFALDVEFSATRLRELAKMDGAIVLDRDVSRIVRAAVQLVPDSSIETSESGTRHRTAERVAKQTGFPVISVSQSMRIVAVYTGNRRYVLEGSDAILGRANQALQTLERYRARLDEVTGTLSALEIEDLVTVRDVCSVVQRIEMVSRIADEISGYVVELGVDGRLLSLQLDELVGGVGPDRELVVRDYLEASRYEGPLEAVLESLAGLHQSDLVDLSQVARVLGFSVGGDSLDSAVSPKGFRLLNRVPRLPGAIVERLVDQFGDLQKLLAASIDDLMTVDGVGEQRARAVREGLSRLAESSILERYV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.582 kDa
Sequence
MDKDKKGAKQDLSEILQFVAPGTPLREGIENVLRAKTGGLIVVGFNDKVKEVVDGGFHINSSFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPEATIPSSETGMRHRTAERVAKQTGCLIIAISERRNVITLYQENMKYILKDIGFILTKANQAIQTLEKYKLILDHAISNLNALEFEELVTFGDVISVLHRYEMVLRIKNEINMYIKELGTEGHLIRLQVSELITDMEQEAALFVKDYVKEKIKDPFVLLKQLQDMSSFELLDDAILLKLLGYSATTNMEEYVFPRGYRLLHKIPRLPMPIVENVVEAFGHLKLIIEADVKDLDEVEGIGAVRAQKIKKGLKRLQEKHYTDRQL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
38.987 kDa
Sequence
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
38.987 kDa
Sequence
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
38.987 kDa
Sequence
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
39.031 kDa
Sequence
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
39.031 kDa
Sequence
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
358 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. To a lesser extent, can also use ADP as substrate to produce c-di-AMP. Does not convert GTP to c-di-GMP. Also exhibits residual ATPase and ADPase activities in vitro.
Similarity
Belongs to the DisA family.
Mass
39.031 kDa
Sequence
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus clausii (strain KSM-K16)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.367 kDa
Sequence
MEERNRTAFIQNLLKLVAPGTPLRAGIDNVLRAKTGGLIVLGYNSEMMNIVDGGFFINSDFSPAYLYELAKMDGAIILSEDGKRILYANTQLVPNNNISSSETGIRHRSAERVAKQTGNLTISISQRRNVITLYQGEYRYALKDIGVILTKANQAIQTLEKYKAVLDQGITNLGALEFEQLVTYSDVIQVIHRVQMVLRIKQEIQNFILELGDEGRLITMQLKELVSNTEQEALYLLKDYAKERTQDVKKTLKELTTLLNEDLLDEQAIIKALGYSRTSNFLEQPASPRGYRILHRIPRLPSQIIENVIDEYGHLSSVMVATEDQLDEVDGIGEARAKMIKDGLNRIQEQLFVDRHI
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus weihenstephanensis (strain KBAB4)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.077 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPDPSIDSIETGMRHRTAERVAKQTASLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEIVSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQMSLEESVTPRGYRIASKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.426 kDa
Sequence
MNDLRLKKDRKLLEILKTMAPGTDMREGLENILRAKTGGLVVLGDNEEVMKLSDGGFKINSEYSASYIYELAKMDGAIILSSDLKKIVRANVQLVPDSSIPTFETGTRHRTAHRVAKQTGNVVVAISQRRNVITIYKDDIKYILRDSSIILARANQAIQTLEKYVAVLDRVMGNLNLLEFEDLCTLHDVVAAIQRTEMVMRVVTEIDRYICELGNEGRLISMQLNELVKNVEQDGMLIIRDYCQNEMNYSKVCETIQSMSSEEFLNSEAISKVMGYGDVPLIDTLISPRGYRMTSKIPRIPFIVIENLVKNFKELKKILEASHEDLDKVEGIGEARARAIKSGLRKLKEQTIIRKQL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus anthracis (strain A0248)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus thuringiensis (strain Al Hakam)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus anthracis
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain AH820)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain G9842)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.062 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPEASIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATIHELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain 03BB102)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain B4264)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.023 kDa
Sequence
MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain AH187)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.111 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILISNAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain Q1)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.111 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILISNAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.041 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus cereus (strain ZK / E33L)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.332 kDa
Sequence
MDSEVKERFARNILKMVAPGTALRTGIDNVLRAKTGGLIVLGYNENMKGIVDGGFYLDCPFSPASLYELAKMDGAIILNEDGTKILYANTQLNPDNAISSNETGIRHRTAERVAKQTGNLVISISQRRNVITLYHGHLRYALRDIGVILTKANQAIQTLDKYKSVLDQDITDLGALEFEELVTFHEVSQVMQRIHMVLNIKGEILNYVNELGSEGRLITMQLNELVSNLEKEVLLLIQDYAKEDDVDPEDVLEQMMKCSNEELLDDSNILKLLGYHKAFNVQEQQATPRGYRILHKIPRLPATIVRNLVHSFENINDMLRADLKELDEVEGIGEARAKLIKDGLSRIQEQLFMDRNI
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.095 kDa
Sequence
MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Length
357 amino acids
Function
Has diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:18439896, PubMed:26014055). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. This rate-limiting step is the accessibility of the active site; mutating the possible exit tunnel (residues 128-130) increases product 2-fold despite Arg-130 being important for ATP-binding (PubMed:26014055). Does not convert GTP to c-di-GMP (PubMed:18439896).
Similarity
Belongs to the DisA family.
Mass
40.54 kDa
Sequence
MGVKSLVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDVIQGGFWLDTDFSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLIMDYSSEEVEEETAQNILQDFITRREPSPISISRVLGYDVQQAAQLDDVLVSARGYRLLKTVARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium avium (strain 104)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
38.821 kDa
Sequence
MTRPTLRETVARLAPGTGLRDGLERILRGRTGALIVLGNDENVEAICDGGFALDVRYAPTRLRELAKMDGAVVLSTDGSRIVRANVQLVPDPSIATDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVGGERHVVADSATILSRANQAIATLERYKIRLDEVSRQLSRAEIEDFVTLRDVLTVVQRLELVRRIGQVIDNDVVELGTDGRQLRLQLDELLGGNDNARELIVRDYHASPEPLSEAQMTATLDELDALSDTELLDFTALAKVFGYPTTTEAQDSAVSPRGYRALAGIPRLQFAHADLLVRSFGTLQNVLAASASDLQSIDGIGAMWARHVREGLSQLAESTITDSLS
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Length
357 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
38.852 kDa
Sequence
MTRPTLRETVARLAPGTGLRDGLERILRGRTGALIVLGNDENVEAICDGGFALDVRYAPTRLRELAKMDGAVVLSTDGSRIVRANVQLVPDPSIATDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVGGERHVVADSATILSRANQAIATLERYKIRLDEVSRQLSRAEIEDFVTLRDVLTVVQRLELVRRIGQVIDNDVVELGTDGRQLRLQLDELLGGNDNARELIVRDYHASPEQLSEAQMTATLDELDALSDTELLDFTALAKVFGYPTTTEAQDSAVSPRGYRALAGIPRLQFAHADLLVRSFGTLQNVLAASASDLQSIDGIGAMWARHVREGLSQLAESTITDSLS
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Peptoclostridium difficile (strain 630)
Length
356 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25965978). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.369 kDa
Sequence
MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLEKYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDYNKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDASIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
356 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
39.368 kDa
Sequence
MSTTTDILPDVHTMRDTLQRLAPGTPLRDGLDRIVRGHTGALIVLGDEENVTSICDGGFEFDVTFAATRLRELCKMDGAVVLSSDGERIKRANVQLIPSPSWPTQESGTRHRSAERTALQTGVPVIAVSESQNTITLYVEGKSHILEEPSTLLNRANQALGTMERYRDRLDQVNTRLHMAELHNYATVIDVVSVIQREEMLRRVGETIDTNVLELGREAKQIQIQLTELRGDNDRERGYIIADYLVTDGIPTDETITEALEAVSGLDDKSLMKPSNIARILGLPPTEEALDEPVVPRGYRTLNRVPRVQKFLMDKLVGEFGNLHALTSASVEEISAVDGVGSLWARHITDGLARLT
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
Length
354 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.832 kDa
Sequence
MRIEKGIGIKNVLKIMCPGTQLREGLENILRAKTGGLLVIGDDEEVMKLVDGGFYINSEYTPSYAYELAKMDGAIVITGDLKKIVCANAQLIPDSSIPTYETGTRHRTAHRVAKQTNNIVIAISQRRNIITMYKGDIKYVLRESSVILGKANQALQTLEKYVAVLERVINNLNLLEFQDLTTLFDVVTAIQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKDGLQYNEVYEHIQKLNSSELLELDAVARTLGRGGIPLMDTLISPKGYRMLSKVPRIPSNVIDNLIKEFEELSNIIDADINDLDNVEGIGEARATAIKDGLKRIKEQVSLKKEI
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Length
354 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.014 kDa
Sequence
MRLEKGMKIKDTLKIMCPGTQLREGLENILRAKTGGLIVIGDNKEVMDTVDGGFTLNSDYSPSYVYELAKMDGAIVISEDLKKIVCANAQLIPDPSIITHETGTRHRTAHRIAKQTNNIVIAISQRRNIITVYKGDIKYVLRDSSVILARANQAIQTLEKYVSVLERVINNLNLLEFQDLTTLFDVVTAIQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKEDFEYNEVYEQIQKLSAAELLDLDAIARLLGHTGDPLVDTLISAKGYRILGKVPRIPSTVIENLIKEFRELNSVIEADLDELDIVEGIGEARAKAIKDGLKRIREQILLNKKI
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Length
354 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.844 kDa
Sequence
MRLEKGMKIKDTLKIMCPGTQLREGLENILRAKTGGLIVIGDNKEVMDTVDGGFNLNSDYSPSYVYELAKMDGAIVISEDLKKIVCANAQLIPDPSIVTHETGTRHRTAHRIAKQTNNIVIAISQRRNIITVYKGDIKYVLRDSSVILARANQAIQTLEKYVSVLERVINNLNLLEFQDLTTLFDVVTAIQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKDEDGHNEVYEQIQKLSATELLDLDAIARVLGHAGESLVDTLISAKGYRILGKVPRIPSTVIENLIKEFKELNSVIEADIDELDIVEGIGEARAKAIKDGLKRIREQILLNKKI
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Length
354 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.321 kDa
Sequence
MRLEKEKELKSILKLLAPGTQLREGLENILRAKTGGLIVLGDSEQILKVVDGGFAINSEYSPSYIYELAKMDGAIILSSDLKKILYANTQLIPDSTIPTFETGTRHRTADRVAKQTGVIVIAISQRRNVITVYRGHIKYVLRDSSVMLGRANQALQTLEKYVAVLDRVVNNLNILEFQDIVTLFDVMTAIQRTEMVMRIVSEIEIYICELGNEGRLISMQLNELIKSVERDGIFMIRDYCQTDMDYDEIYRQIQEISSDDVLNLDFISRAMGYVGVPLVDTLISPRGYRMLSKIPRIPATVMDNLVKNFKELKEIMEASYEDLDRVEGIGEARARAIKNGLRRLREQIMIDNKF
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium perfringens (strain 13 / Type A)
Length
354 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
40.004 kDa
Sequence
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEYSPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIAIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQDLATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYCYDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISNKVPRIPSNVIENLVGHFGKLKYILEAGNEELDQVEGIGEARARAIKNGLRRIREQVALNKNL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium perfringens (strain SM101 / Type A)
Length
354 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.991 kDa
Sequence
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEYSPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIAIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQDLATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYCYDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISSKIPRIPSNVIENLVGHFGKLKYILEAGNEELDQVEGIGEARARAIKNGLRRIREQVALNKNL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.655 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain 657 / Type Ba4)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.669 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVLTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.655 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Kyoto / Type A2)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.641 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Okra / Type B1)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.655 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.655 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Length
353 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.671 kDa
Sequence
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGSIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Length
352 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.185 kDa
Sequence
MKDERIVLALKSVAPGTPLREGLEQILRAKTGGLIVIGDTAKIMEVVEGGFAINTDYSPAYLYELAKMDGAIILSEDGKKILYANAQLVPDPAIPSSETGIRHRTAERVAKQTNALVIAISQRRSVITLYQGNFKYSLSEVSVILNKANQAIATLEKYRAVLDKTLMRLTNLEFDDMVTLLDVAKALQRVEMVLRIEREIERYIWELGSEGRLISMQLEELIANVEDEGLLIIQDYSLLGPEKTPEGILSLIRTWSSEDLLDYSLIVRALGYPGSASILDQPVSPRGYRILDKIPRLPVAVIENLVQTFGNLKNIMSASIEELDDVEGIGEVRARSIKEGLKKLREQTNYTL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Length
352 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
39.966 kDa
Sequence
MVPQELIEKIKLISPGTELRKALDDIISANFGALIFLVDDPKKYDDIIQGGFWLDTDFSAEKVYELSKMDGAIVLSEDLTRIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFDKLLSDLEVLELENRVTLADVVRTLMKGVELLRITEETRPYIVELGEEGRLARMQLRELTEDVDDLMVLLIMDYSSDEVDEETAQAILQDFVTRREPSPISISRVLGYDVQQVSQLDDILVSARGYRLLKTAARIPISIGYNVVKMFKTLDQISKASVEDLKKVEGIGEKRAKAISESISSLKHRRTSE
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Length
352 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
40.001 kDa
Sequence
MVPQELIEKIKLISPGTELRKALDDIINANFGALIFLVDDPKKYEDIIQGGFWLDTDFSAEKLYELSKMDGAIVLSEDITKIYYANVHLVPDPTIPTGETGTRHRTAERLAKQTGKVVIAVSRRRNIISLYYKNYKYVVNQVDFLISKVTQAISTLEKYKDNFNKLLSELEVLELENRVTLADVVRTLAKGFELLRIVEEIRPYIVELGEEGRLARMQLRELTEDVDDLLVLLVMDYSSEEVDEEAAQDIMQDFVKKRDPSPISISRALGYDVQQVAQLDDVLVSARGYRLLKTVARIPLSIGYNVVRMFKTLDQISKASVEDLKKVEGIGEKRARAISESISSLKHRKTSE
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Length
351 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
Similarity
Belongs to the DisA family.
Mass
39.074 kDa
Sequence
MEDRSGFWQVLQQLAPGTALREGLESILLARTGSLIVVGDSPEVLALVDGGFRLDCEFTPTRLYELAKMDGAIILTRDAQRILYANAMLVPDPSIPTSETGTRHRTAERVARQTGELVISISQRRDLITLYKGPMKYILRDFAVVLTKANQALQTLEKYKLVRDQAVARLSALELDDMVSALDVALVVQRTEMLLRIGKEIERYIVELGTEGRLVAMQLEELLAGVAAEGLLIIRDYASTDDPQHAAALRQQMAEWTYEELQDLAAVARLLGAGALDSPLGARGYRMLRRIPRLPAAVIENLVARFGRLQRVLAASLEELDDVEGIGEVRARAIQEGLRRMRMQFALERQL
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Length
349 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
39.96 kDa
Sequence
MTKQDLMDIIVKVAPGSPLREGVDYILDAGIGALIIIGYDDEVEKVRDGGFLIDCDYTPERIFELSKMDGAIILNDDCSKILYANVHVQPDNSYSTTESGTRHRTAERAAKHLKREVVAISERKKNVTLYKGNLKYRLKNFDELNIEVGQVLKTLESYRHVLNRSLDSLTILELDDLVTVLDVANTLQRFEMVRRISEEITRYLLELGSRGRLVNMQVSELIWDLDEEEESFLKDYIDDETDTDSVRRYLHSLSDSELLEVENVVVALGYSKSSSVFDNKIAAKGYRVLEKISKLTKKDVEKIVNTYKDISEIQEVTDEDFSAIKISKFKIKALRAGINRLKFTIEMQR
Protein
DNA integrity scanning protein DisA: disA

Gene
disA
Protein
DNA integrity scanning protein DisA
Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202)
Length
344 amino acids
Function
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
Similarity
Belongs to the DisA family.
Mass
37.633 kDa
Sequence
MALLAPGTPIREGLDRIVNGRTGGLIVLGDGPEINGVCSGGFPLDVRLTPQALRELSKMDGGLVVSSDHERIKAAAVHFVPDGSLPTLETGTRHRTADRLSQQTGVPVVVVSASMSVMSLFLNGRRYLIERPEQLLARANQALATLASYRGRLVDEAENLTTLEIRDQVQVRDVAAVAQRVEMWRRIDAEVRGYVSALGVEGRLVQLQRNELSLGVEDLGRLLTDDYRPNSVAPGGFSLSGLQKLSWEDLLNVTMVAETINLGPAEHPLDSPIRARGHRQLTLMTDLSSRTIQRIIDHFSDLQSLVSASTSELGDIKGVGLRRAREIRQGLESIFEGDQRTHHH
Protein
DNA integrity scanning protein DisA: disA