Protein
Deoxyhypusine synthase
Organism
Caenorhabditis elegans
Function
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Similarity
Belongs to the deoxyhypusine synthase family.
Sequence
MSTNEAAASQEDIALAQGAVLVKSCQVPDGSIPIRGFDFSTASGPDFSLSAILSSYMSTGFQATHLAQAIQQVNQMLSLRDTPLTCDDDEKLFPYPEGRQKRSCTIFLGYTSNLVTSGLREVLRYCVQRNLVDCIVTSAGGIEEDLIKCLKPSYLGTFTMDGAKLRSNGMNRAGNVLIPNDNYCAFEDWLMPILDECLVEQEEKHLNWTPSKLIQRLGERIGDESSILYWAAKHRIPVFCPALTDGSLGDMLYFHSVKSSPGLRVDIVEDVRHINTIAVKSFKTGSIILGGGVVKHHINNANLMRNGADHTVYINTGQEFDGSDSGAQPDEAVSWGKVKPSAGAVKVHAEATLVFPLLVAETFAKHEGHKD