Function
Involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin. DesVIII assists the folding of the DesVII polypeptide. However, unlike chaperones, it remains bound to DesVII during catalysis, forming a tight DesVII/DesVIII complex. Although the formation of the DesVII/DesVIII complex is essential for the catalytic activity, DesVIII is unlikely to be involved in catalysis directly.
Sequence
MTDDLTGALTQPPLGRTVRAVADRELGTHLLETRGIHWIHAANGDPYATVLRGQADDPYPAYERVRARGALSFSPTGSWVTADHALAASILCSTDFGVSGADGVPVPQQVLSYGEGCPLEREQVLPAAGDVPEGGQRAVVEGIHRETLEGLAPDPSASYAFELLGGFVRPAVTAAAAAVLGVPADRRADFADLLERLRPLSDSLLAPQSLRTVRAADGALAELTALLADSDDSPGALLSALGVTAAVQLTGNAVLALLAHPEQWRELCDRPGLAAAAVEETLRYDPPVQLDARVVRGETELAGRRLPAGAHVVVLTAATGRDPEVFTDPERFDLARPDAAAHLALHPAGPYGPVASLVRLQAEVALRTLAGRFPGLRQAGDVLRPRRAPVGRGPLSVPVSSS