Organism
Xenopus tropicalis
Function
Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1. Can exert long-range effects in the embryo (By similarity).
Similarity
Belongs to the TGF-beta family.
Sequence
MLSLACFFSFLLMVKSSPLTFQERMLLKALGLNTRPNPIAPGPVPKSLRDIFEKGINKDNPCMMEGFGVPGNIVRSYRDQGPVAAMEEPQESLCLKKFLFFDLSAVENKEQLTLGQLEIKFKHNSYYGQQFHLRLYRTLQLSLKGMRESKMNRKLLVSQSFRLLHKSLYFNLTKVAKDWKTPEKNMGLLLEIYASSKLAGDNRSFAVCEPIQSFIYTSLLTVSLDPSSCKTPRAKRSTHSSPPTPSNICKKRRLYIDFKDVGWQNWVIAPRGYMANYCYGECPYPLTEMLRGTNHAVLQTLVHSVEPESTPLPCCAPTKLSPISMLYYDNNDNVVLRHYEDMVVDECGCK