Function
Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Essential for development (PubMed:19326441, PubMed:21078872). Required for cell signaling and/or cell proliferation (PubMed:19326441).
Sequence
MSHLTGTRVSTFNESFLNENEHDSNAVLMELDKGLRSTKQGIQCEAVVRFPRLFEKYPFPILINSSFIKLADYFVSGSNLLRFWVLRVCQQSENHLDKILNIDSFVRCIFVVMHSNDPVARALLLRTLGAVSRVIPEKQQVHHAIRRALDSHDTVEVEAAIYASSCFAAQSSSFAISMCAKISDMIESLQVPVPMKLLLIPVLRHMHHEATTASLVSRLCMDLLPKYPAQSFVVAIIDTLTQLSSRTLVGVPGQLDVLLDFMQDLRTPVRIQVLRSFNELAGRQSVHAWPKPAIKALIDRFELCTNSKEQFLFLSILLKLSECPLTCQQLLREHRVALLRLCIQCISKLDDYTTATQAMAVLSVLVAFGLKKKGSGEQVDDILHMVNLHMEGLLLCTAKRSECTRDLRRVLTYGIRITKANAEFGTSFIGIVTNSLGDKGAYPPANAELMCEALAGLCEHFQLRKYAFSTAEDLIVDENAMDTDELPPPKINPMLARLPLILHKLNTIIDQENCDQQLRSVEILSSLVLQTTMGCYLPQKVVQCFEKCLGRLNCWTLYRIARTASRYGHHYVAAHIYTKVSQIVISDHMHYFLVALSQISQAECILNYGLEYAYMRDNYAPKVAPEPLIPLMKRLEMASNLYQQALASLRAGSSPQHPCTFQLEYLKIRAQFLQTLHLAVTVKNAQVIVPPPAIAGSLAQNSRDYLQKFGHVTNQLRKLVKALKACEETYARLYKSSFDADHVTLEFLEVAEFQCALFAHIIESICYATPPEPPVFLTTGDHPETRYFAASCQRMEQMQKNLPQEPANAKTISNRHLDVIIAQIEIITKTPLCLPRYFFQILQSTQIKLSVSPQPRSATEPVNVQSGSNLVIKVEGVLQHFSKQKKHFRRVESVQLSLTSQLITPPPRSSQELPKQGANDTVTLNQIVKPQRDFLSGSFLLPISNGGHFQVTLETFVVDENGITWCTGPKSSMVVRVLEDPSKQGAPAPSTSQAVGQTRRF