ddi-1

DNA damage-inducible protein 1

439 amino acids

Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.

Belongs to the DDI1 family.

47.77 kDa

MQITIAIQDTTGDDQDFLSLQVFPDMTLETLRNSIQAETSHHPSTQHLYHNGNLITDNSKTLTQLNVTDGDMLALHVRETQRATAVPESQQGRPAAPPQQDPEFLRLQFLANPALRAEVERTAPDLAAAINDPQRWAQLFRERYDREQRERAERHRIIQQLNEDPFNPEAQARIEEIIRQERVTENLQTAMEHNPEVFGTVHMLYLDVEVNGAKVKALVDSGAQATIMSPDIAEACGIMRLVDKRYGGIAKGVGTAKIIGRVHTAPVKIGSLFLPCSFTVMEGKNVDMLLGLDMLKRYQACIDLAKNALVIQGEEIPFLGEADIPKATEEALQDEPTIEGPGGTTIGQRTGAVSGPGTAQHRQGQAGPSTAAQPGPSAPAPAPASASAPAPRAPQARSFPREHIEQLVALGADEQKAIRALEATDGNVEYAASLIFEGF

ddi-1

Protein DDI1 homolog 1

389 amino acids

Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3.

Belongs to the DDI1 family.

43.716 kDa

MSFQVSVAVNDGPFQKKSVTPNTTIGDLNNDAILIWKDTAIVYDISDESKNFGPTVTLEQLGVTQISMVYIYTTAFPCPSGDLRSIVPAQVRLISQFASAASSIFNGQSSSSAQSAQRTRRVEQDDEGEKSMFSRKLLDSPATFKALSENMFFRLKNEPHKLGYGLPELVERFLAKKDMTYKEFEQMFRSYVEEEVHKEEIIKNNPNSAEAKMFLEAKRNKELIDEQYLHSMTHHPEDMIAVTMLYINLTINGVPVKAFIDSGAQKSIMSMACAERCGLNGLIDRRFQSMARGVGGTEKIEGKIHLCDVKVEDAHFSCPFEVMARREMDLLIGLNVLRKHGCCINLKTSRLEFGNGTTTPFLQSNEIDSHLKEIMALPEEEMQFEDGST