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dct-1

Gene
dct-1
Protein
NIP3 homolog
Organism
Caenorhabditis elegans
Length
221 amino acids
Function
Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes (PubMed:11114722). Has a role in lifespan and tumor growth (PubMed:16380712, PubMed:17934462). Required for the induction of mitophagy under stress conditions (PubMed:25896323).
Similarity
Belongs to the NIP3 family.
Mass
24.843 kDa
Sequence
MSSFLEFAKPKMLDIKRKINFASGEKTDESVQPQQQTEQSSAQQTTPSAKAVSNPFITPLTESTPGMSESWVELAPSRTSLCSSVDINMVIIDEKDKDSRLSPVSIAQSPHVEFESLEQVKYKLVREMLPPGKNTDWIWDWSSRPENTPPKTVRMVQYGSNLTTPPNSPEPELYQYLPCESDSLFNVRVVFGFLVTNIFSFVVGAAVGFAVCRKLIKHHRQ

Gene
dct-1
Protein
BNIP3 homolog
Organism
Caenorhabditis briggsae
Length
220 amino acids
Function
Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth (By similarity).
Similarity
Belongs to the NIP3 family.
Mass
24.633 kDa
Sequence
MLDIKKKINFANVSGEKTDESSSSSAQQSSEQQQAAQPLAPQQTTPTAKATNPFITPMTESTPGMSESWVELAPSRTSLCSSVDINMVIIDEKDKDSRLSPVSIAQSPHVEFESLEQVKYKLVREMLPPGKNTDWMWDWSSRPENTPPKTIRMVQYGSNLTTPPNSPEPEMSQYMPYESDSLFNVRVVFGFLVTNIFSFVVGAAVGFAVCRKIIKHHRHY