Protein
Dicer-like protein 2-2
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Function
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).
Similarity
Belongs to the helicase family. Dicer subfamily.
Sequence
MTSSTDYHADSTPGTTSNMELRIREYQLEMLNESLKRNLIVVMPTGTGKTQVAILRILADIDKGNSDKFVWLLCPTVALSEQQYIQYATVFLPSGAEDKAIWDNALSGIKIAVSTYQVLYDALSHGFVKLSQMSLLIFDEAHHCKKDHVANKIMQVHYHKQHQSGVQNLPKILGLTASPILSDLSSLEIVESNLGSICKTPRQYYAQLLQFTNRPLILPRLPTYTIPNCSVKAPILEKLCGILSSEDEVPSSSKMKSKQLKHIRRFMQTSESINQELGIWAATEYMRKSIMHFKESMRMGAEKTNISNYGKDFAMEILTRLGKLQDCSPAIQPEEISPMCQCLLDELSKAYREGFCGLVFVTQRATVLALKWLIENHPLTSHLFTCGTFIGMSTTQYSKTELGNLHDIRNQTETLEKFRQGSLNLIITTDALEEGIDVPACNTVLNFNCQLSLKSFIQRRGRARRENSQFIIIMEDESGPRYLKRLEMEEIELVQKLQNAERRQIPANELDFDKYERISLSLDIDRTGAQLIMREAVGYLYNFCSKLPAQLYVSNKPLFTYERNNYGRFRAVVKLPSNLDPSLQSFSSSRSWSRLKYAREDAALQAYKALYQAGLVNDYLVPTQVSDHLEGDIIFRSHYSIQNQLDPWQDIALLWKLDSQLYAHNLRIIRPEEDEIHLHMILPTQLDTTIHIPLFIDYCTTYTAILTPGHPITTDISLCQQVTNLIFQSVYRDHCSRRNLDYAFLLVPELEETKLIEFLERYSGSVSLTELLNQEATPSALGLLRSHTRPSRPLLVEPWVAGECFLPDELSISSFDAKVKYMTNRRNFLSHGNLAAGKSTNCEARIGLEANVKSMSVRDFFVDKLPSMFAQVALFTPSISHEVEVYMIAQILRQELSLRSVTPWQRIDLLAIAIRPTSIEHRATFRLLAFIGDAFMKYLFAMQLFLHHHLWHEGLLSSLKQRNLSDAGLAHAIHQSGLGKFLISKHLNGKRWVPPLVSGIEPASNEARQRSIGAATLADMTKAVVGAAFTDGGLNQAAACASVMFPKLKSWNASSLHDGTYSKTRPENAVASTAIVDMEELLGYTFTDKSLAVESMTHPSCTGLVQTTSYRRLSFLGASVLEWIVVSYLHRHAQVMNPQRMQSLKSAFTNNTFLTFIAITFHQVREQNHIDVDDEHNVHKNVTTCSIRLWDFLRLHSDALSTELSDFVQKSSEKADAIKHELWEQRFYPWVRLRALGDMRVLSDIIQSIFGAVFIDSQATLASCDALAEKLGIVPLLEHFISHQITTDHPKDTLQAILPGRKVSYQICVDKVHPGTLRCSALADSSEIASVEGQMNDEVIKMQAAETAVRLLRKGFALSETS