Protein
Neutral ceramidase A
Organism
Dictyostelium discoideum
Function
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 3.0. Has no activity toward glycosphingolipids, such as GalCer and Galbeta1-3GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta1-1'Cer or sphingomyelin.
Similarity
Belongs to the neutral ceramidase family.
Sequence
MKRSIVFIYSLVILLLSVGFIDAFKISIENHIKLSDDSSYQIGTGIYDITGPGAETNMMGYAMPGQITGGIHFRQRARAFVFIDSEGNRAVYVSTDSCMIFQEVKIQVIQDLQEIFGPTLYTHDNVLLSGTHTHSGPAGFSEYALYGITALGFYKKNFDTICDGIVQAIVKAHKSVQPARMLTQQGELWNSNINRSPYAYDNNPEEEKAMYDANVDKNMTVIRIEDMSGNPFAAISFFGVHCTSMNNTNHLISGDNKGYASYLWEKHANGQSSLPGTGPFIAAFGQSNEGDVSPNTRGPTCRDGKPCDYKTSTCNGKVEECWALGPGTDGDMFESTQIIGGNQFNKALELFNNATIQVSGKIQYRHTWKPFTNVSVEAPYNSGVEGATTCRGAMGYSFAGGTTDGPGAFNFIQGDNSTTNPFWNFIGGIIAKPTPQQTACQAPKPILIDVGMVEPIPWVPDVMPLQIITLGQIVLVAVPGEFTTMSGRRLRNTVREIIGQSIENPIVLIAGLANTYSGYIATFEEFQVQRYEGASTVFGPHTLGAYQQEFANLAQSIVDGSQADPGTFPRNMSGHTPFFLPPVIVDVAPKFDDFGDIYTDVSTTTPYSINQTVTVIFYGANLRNNFMTESSFLTVDQLQSNGQWTTILNDGDWDTKLYWKMHDLGFSLITVDWTISPITQPGTYRITHSGYAKKNPFSDNLTFYQGISSNFNVQ