dbr-1

Lariat debranching enzyme

511 amino acids

Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).

Belongs to the lariat debranching enzyme family.

57.728 kDa

MSTEETVDEVPCCGSHDEAQCTIQHDLAPQPLIVEEEVNNGEKKAKIAVVGCSHGEMDAIYETMALIEEKKGYKFDLLICCGDYQAVRNHGDLPHMSIPPKYRSLQTFYKYYSGEKKAPVLTLFIGGNHEASGFLCELPNGGWVAPNIFYMGFANCIQFAGLRIAGLSGIYSHGDVEFSHYERPAFAERDVKSAYHVRNVDMFRLRQLKAANNDKLSNPIDIMLSHDWPGGIPDFGDSAWLFKKKDLFEADHKSGKLGNPALMKLIYDCRPRYYLAAHLHIKFAALVPHKGSGSERPQPTRFLSLDKPIPGRQFMQALEINVASDAKMELSYDPEWLAILKNTDLLTTADKTKIVLPDRIGSVPCVYDRKDFRPTAEEMEEITKLGDLTIKTDTFKHTAPPLKEDTSEAKNVPPSAYYRNPQSAEFCQWLGIKDLNYLLVEKSSDYVGIPFYMMPDSGETEFKSNQDEVDFGEDDFIIDRGHGSEEPEAKKSRLEEEKKKKKKKIENLKTL

dbr-1

Lariat debranching enzyme

500 amino acids

Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).

Belongs to the lariat debranching enzyme family.

56.682 kDa

MSSKNPVDEQPCCGSHEGSHQDPAPETLVVEKEVNNGEKKIRIAVVGCSHGEMDAIYETMTLIEQKNGYKFDLLICCGDYQAVRNYGDLPHMSIPPKYRSLQTFYKYYSGEQKAPVLTLFIGGNHEASGYLCELPNGGWVAPNIYYMGFANCIRFANLRIAGLSGIFSQGDFQFSHYERPSFSERDVKSAYHVRNVDMFRLRQLKSDNENKISNPIDIMLSHDWPGGIPDFGDKEWLFRKKDLFEADHNSGKLGNPSGMKLIYDCRPRYYLAAHLHIAFAALVPHKGSGSGRPQPTRFLSLDKPIPGRKFMQALELNVADDAKLELSYDPQWLAILRNTDLLTTGTKEQLILPDMASNRPCVYERKDFRPTAEELKEIEKLGDLTIRTDSFQQTAPPLKEITESSKNVPPSAYYRNPQSAEFCQWLGIRDLNQMLVEKTSEHVGTPYYMMTQDDANAKPNQDDVDFGDEDFVIDRGHTSDEPEAKKSRLDEDKFEAVPSE