Protein
Anthracycline biosynthesis protein DauV
Organism
Streptomyces sp. (strain C5)
Function
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Acts jointly with DoxA in the conversion of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield carminomycin and daunorubicin, respectively (By similarity).
Sequence
MTRFAPGAPAWFDLGSPDVAASADFYTGLFGWTATVVSDPGAGGYTTFSSDGKLVAAVARHQIDTPYHRPYGPGNDQHGMPAIWTVYFATNDADALTKRVETAGGDVIMTPMDVLGLGRMAVFADPSGAAFAVWRKGVMEGAEVTGVPGSVGWVELVTDDIGTARGFYRATLGLAPADTGRKGVTDPVWHIHDTPVAGTRELGTTGAVRPHWAVLFSVHDCDATVRRAVELGGSVENEPVDTPRGRRADLLDPHGAGFSVVELREAYPAAADGAS