Protein
Aklanonic acid methyl ester cyclase DauD
Organism
Streptomyces sp. (strain C5)
Function
Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the cyclization of aklanonic acid methyl ester to yield aklaviketone.
Similarity
Belongs to the polyketide cyclase DnrD family.
Sequence
MSPQIDLVRRMVEAYNTGKTDDVAEFILHEYLNPGALEHNPELRGPEAFAAAVTWLKYAFSEEAHLEEIGYEENGPWVRAKLALYGRHVGNLVGMPATGRRFSGEQIHLIRIVDGKIRDHRDWPDYLGTYRQLGEPWPTPEGWRPCPPPPRRRHDRSTDTP