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dasR

Gene
dasR
Protein
HTH-type transcriptional repressor DasR
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Length
254 amino acids
Function
Global regulator that is part of the nutrient-sensing system. In the absence of N-acetylglucosamine 6-P, represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3' (By similarity).
Mass
28.226 kDa
Sequence
MSTDVSSAENEGGAPIRTARVPKYYRLKKHLLDMTETLPPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYITADDTLAGLLDITAGGRVLRIERLRLASGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSLDKDGRPVEWVRSVYRGDRYKFVARLKRPQD

Gene
dasR
Protein
HTH-type transcriptional repressor DasR
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
254 amino acids
Function
Global regulator that is part of the nutrient-sensing system. In the absence of N-acetylglucosamine 6-P, represses the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3'.
Mass
28.344 kDa
Sequence
MSTDVSSAENEGGATVRTARVPKYYRLKKHLLDMTRTQTPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYITADDRLAGLLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSQDRTGQPVEWVRSVYRGDRYKFVARLKRPQD

Gene
dasR
Protein
HTH-type transcriptional repressor DasR
Organism
Streptomyces griseus
Length
253 amino acids
Function
Regulates the dasABC transport operon involved in glucose-related morphogenesis. Essential for development.
Mass
27.946 kDa
Sequence
MGAEGAVRGARPVPVRAQRVPKYYRLKRHLLDMTDTLPPGTPVPPERTLAAEFDTSRTTVPQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQGLEPTSQLLDIGYVTADDTLAGLLDISTGGRVLRIERLRLASGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSVDGQGEPVEWVRSVYRGDRYKFVARLKRGTD