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dapdh

Gene
dapdh
Protein
Meso-diaminopimelate D-dehydrogenase
Organism
Lysinibacillus sphaericus
Length
326 amino acids
Function
Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity, since alpha-ketoglutarate, pyruvate, oxaloacetate, glyoxylate, alpha-ketobutyrate, alpha-ketovalerate, alpha-ketocaproate, alpha-ketoisocaproate, alpha-ketoisovalerate, and phenylpyruvate are not substrates for the reductive amination reaction, and L,L-2,6-diaminopimelate, D,D-2,6-diaminopimelate, DL-alpha-aminopimelate, meso- and DL-2,5-diaminoadipate, L-djenkolate, L-cystine, L-lysine, S-(beta-aminoethy1)-L-homocysteine, L-ornithine, L-arginine, L-alpha,gamma-diaminobutyrate, L-histidine, L-phenylalanine, L-tyrosine, L-glutamate, L-aspartate, L-leucine, L-valine, L-methionine, L-serine, L-alanine, L-alpha-aminobutyrate, D-lysine, D-glutamate, D-leucine, D-alanine, D-phenylalanine, epsilon-aminocaproate, 7-aminoheptanoate, and 8-aminooctanoate are not substrates for the oxidative deamination reaction. Cannot use NAD(+) or NAD(+) analogs instead of NADP(+) for the oxidative deamination reaction.
Similarity
Belongs to the diaminopimelate dehydrogenase family.
Mass
35.576 kDa
Sequence
MSAIRVGIVGYGNLGRGVEFAISQNPDMELVAVFTRRDPSTVSVASNASVYLVDDAEKFQDDIDVMILCGGSATDLPEQGPHFAQWFNTIDSFDTHAKIPEFFDAVDAAAQKSGKVSVISVGWDPGLFSLNRVLGEAVLPVGTTYTFWGDGLSQGHSDAVRRIEGVKNAVQYTLPIKDAVERVRNGENPELTTREKHARECWVVLEEGADAPKVEQEIVTMPNYFDEYNTTVNFISEDEFNANHTGMPHGGFVIRSGESGANDKQILEFSLKLESNPNFTSSVLVAYARAAHRLSQAGEKGAKTVFDIPFGLLSPKSAAQLRKELL