Function
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2/dsh and impedes the degradation of beta-catenin (ctnnb1-A and possibly ctnnb1-B), thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. Also promotes catenin delta/ctnnd1 stability which in turn promotes zbtb33/kaiso sequestration and thus is involved in the regulation of zbtb33/kaiso-mediated transcriptional repression. May also bind to and directly stimulate the transcriptional activity of tcf7l1-A. Required for eye development and neural patterning.
Similarity
Belongs to the dapper family.
Sequence
MKPIPSPEPPGQLRLTPRRKDKGEAEWERHRTRERLEATLAGLAELDCLRHRQQLLVQNVLSPGTHGQDAAPTGDSPRSDEQKLLEENISLLKKQLNCLRKRDAGLLSQLHELDKQINDLKIDSEKTEETDSRPSSGFYELSDGTSGSLSNSSNSVFSECLSSCHSSTCFCNPLETSLNLTDGQAKSAEDFLEWLDYRESQHETGTVRCSFSAPHSNSVEVTADVHPKYQCDLVSKNGNDVYRYPSPLHAVAVQSPMFLISVMGNIKAEEPEEEIGPNDNDDCIVPELDHLKDEDSFLHQSSLCSLPLSSGKKMDGYILSIIHKKAHPVRTNKPRTSVNADPGKGILRHGSICVKQTVGVSQSNAVNLKNSKQTCLHSAGMISVDNSTYPSLKPCSKESLSEQLESKRMPSISTYPSCNVNELQSQNNSRNTVKSVCQGLARGSVAMTSNVQKENVTPNAPANLPNASSSVCNGSPRESTQNSALLPQEIKVVPPVKRVSLKNTLLSYHESSSFEERPPLDFKSEGSSSQSLDEGMLVNAHYIPAQQHGVKLHKNTKNVKIVKSSTLKHRADVQYVLENGSQTLKEKSKVVGKKCRFPEDLDTNKKVKKSTPRVKKIVHPHFEPAAVGRNPVAVRSGIKSHGHPKDVVLAKPKHKRSDYRRWKSSAEISYEEALRRARRRVQREMMGVCAQVPFSHASPYAYIASDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSLSEVEFVGESTTSSDTDESGGLIWSQFVHTLPMQATATAELQTTAKAFIKIKASHNLKKKILRFRSGSLKLMTTV