Protein
F1845 fimbrial protein
Function
Hemagglutinins of uropathogenic E.coli mediate adherence to the upper urinary tract. These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)). C1845 is a strain responsible for diarrheal disease.
Similarity
Belongs to the Dr-adhesin family.
Sequence
MKKLAIMAAASMIFTVGSAQATFQASGTTGITTLTVTEECRVQVGNVTATLARSKLKDDTAIGVIGVTALGCNGLQAALQADPDNYDATNLYMTSRNHDKLNVKLKATDGSSWTYGNGVFYKTEGGNWGGHVGISVDGNQTDKPTGEYTLNLTGGYWTN