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cypD

Gene
cypD
Protein
Bifunctional cytochrome P450/NADPH--P450 reductase 1
Organism
Bacillus subtilis (strain 168)
Length
1061 amino acids
Function
Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of a range of long-chain fatty acids, with a preference for long-chain unsaturated and branched-chain fatty acids over saturated fatty acids. Hydroxylation of myristic acid occurs mainly at the omega-2 position. Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:15375636, PubMed:15122913). Is also able to catalyze efficient oxidation of sodium dodecyl sulfate (SDS) (PubMed:21048857).
Similarity
In the N-terminal section; belongs to the cytochrome P450 family.
Mass
119.468 kDa
Sequence
MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQIHTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAHNILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGFNYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLVDSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLLSFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAFSLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHAYKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHISVQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVARELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIKPGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQLDEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENRELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTLSASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSAEGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQASITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMVGPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTVHTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQAVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI

Gene
cypD
Protein
Cypemycin cysteine dehydrogenase (decarboxylating)
Organism
Streptomyces sp
Length
190 amino acids
Function
Involved in the biosynthesis of the lanaridin cypemycin.
Similarity
Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
Mass
20.75 kDa
Sequence
MNVEKFEGAELHVHVTGSISAALVPWWIHWLREFQPELVVNVSVTPAASRFLAVRALRHLANGKVWVDSWDDPDVPPEVNSGKSGASECFLVFPATLDTVMRLAQGRADSPALMMLQLTDAPLVIADTFPGSNEIVENNVQTLKLRPNVEFAPRVNGVRASNRQTAEVGFNLPGALAAANRMRKEGRSGE

Gene
cypD
Protein
Peptidyl-prolyl cis-trans isomerase D, mitochondrial
Organism
Dictyostelium discoideum
Length
174 amino acids
Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Similarity
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
Mass
19.016 kDa
Sequence
MTGIIRNKVFFQIKQGNTPLGRVVFELYNDIVPKTAENFRALCTGEKGIGKSGKPLHYKGSSFHRVIKNFMVQGGDFTHGTGIGGESIYGRTFNDENFLVKHKIGCLSMANAGKNTNGSQFFITTAETPHLNGGHTVFGEVVEGFDIVKKVENAETDRSDRPKAACVIEDCGQL