cyk-3

Ubiquitin carboxyl-terminal hydrolase cyk-3

1178 amino acids

Ubiquitin-protein hydrolase which cleaves ubiquitin from ubiquitinated proteins (PubMed:12006614, PubMed:11683918). Plays a role in embryo osmoregulation (PubMed:12006614). Probably by regulating osmosis, controls actin redistribution in the 1-cell embryos and thus actin-dependent processes such as cytokinesis and P-granules segregation (PubMed:12006614, PubMed:11683918). During the first embryonic mitotic division, involved in the formation of a functional microtubule organizing center provided by the male pronucleus (PubMed:11683918).

Belongs to the peptidase C19 family.

134.123 kDa

MGNTLTGRSNAIAPIISAEDAKTYISDEEYRRIRQAFQRFKNGCINYDEFCYHVLGGAQIPEEKRRLLFSFFSHGAETISFDNLLSSLVGLCRVEEVQSRFIEEYHEFASWGLSPPKLTIPLNDSYISFYEVMSYVTHLSVNEVIELEKVFATISDRAVCKLNEEKWKQALGGCFPDSYAERLFAVFDENRDGQIDFRELVCTLSALCRGPLPGRISQLARIWDVDCDKLLSDEELSNMYKDLNVPEEHQTVTKSSNGKSALVDFGIWAQENEKYVNEYYSMALQIGHICLGLRPESRKMELQIVNEFEKRASELPLSEWNIVASGWHAELRSFLEADKNPNPIDNSGIKGTREDSWTSKVACISAESARLKPDLIPSDYIRVPVPLWRAWLRWHGCALTVDSQFTRKYLDGEFFEDNKPALELYPLEILLLGHDRKKSQDGTENTPRSLTSWACAQVSRSMTVDELLALCKTELRLGDGDARLWQVVKENEEGNVLLDDGAQNLHQLYSSLGKTKKVNKMKLLLEVRERGTGVWPEELRASLSGKQITAASTLSSNAQLSDSSGRPGAVGLVNYGNFCYRNAGIQCLARVSPLTQYFLDEDNLDAIKRGNLRRGDAAETTIEYAKLLREMWAAKKKNIAPNDFNDAIRLSSDMFECSEQHDCQEFVAFLLDQLHTSMYESNKSLHPSPEESEGTDSNKLSDSSKKKEADKEEADEEKAERSWTEYEKQNESLVTQLFTGQLRSRLICRTCQSSSSVFEPFTSLSLPIGFEDVDLYQVIVVHRDGRIPRRYGFRLSRDSKVGNLREVVAVSSGISMSHLTIQCMSSKGTLMSRSPNHRSSNLRDELPLSSFPSGARLYALELPESTGEDQWRVAMHRKLQYNHEPYILGSTAGFIVSRFGLPLIVGLDEEVTGKKLYEDVMYQMHRFMEHSVNSSSSRAHDPCEDENSGYPFTLCLVDPNYEWCGQCPALRFCRGCPIRPDESKVFIPANCPIAVDWLPIALYLRYNHSQEQACEDDPSVAETWSRHFAPSSLEHCIEKFSCPETLDAAIQCDRCEKKTMRDKVMTIWKLPKYLIIHLKRFEFLREQGRMGKCKRTVNFPLKHFDPAPFVDKPDGNTYECIALANHYGQLSCGHFIAYAKSNEDKWLLLNDCSVREVSEEEVDKQGAYLLFYERKDVK