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cwn-1

Gene
cwn-1
Protein
Protein Wnt-1
Organism
Caenorhabditis elegans
Length
372 amino acids
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1 (PubMed:17942487). Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). Also acts with the Wnt ligand egl-20 to direct HSN neuron migration (PubMed:16516839). Acts through the Wnt receptor cfz-2 to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with Wnt ligand cwn-2, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Probably by activating the Wnt/Frizzled pathway, may regulate vulva development (PubMed:17942487). May act redundantly with other Wnt ligands such as cwn-2 and mom-2 to control seam cell polarity (PubMed:22022276).
Similarity
Belongs to the Wnt family.
Mass
41.975 kDa
Sequence
MLKSTQVILIFILLISIVESLSWLALGLAANRFDRDKPGTSCKSLKGLTRRQMRFCKKNIDLMESVRSGSLAAHAECQFQFHKRRWNCTLIDPVTHEVIPDVFLYENTRESAFVHAISSAAVAYKVTRDCARGISERCGCDYSKNDHSGKSQFQYQGCSDNVKFGIGVSKEFVDSAQRRVLMMKDDNGTSLLGPSQLSADGMHMINLHNNQAGRQVLEKSLRRECKCHGMSGSCEMRTCWDSLPNFRHIGMAIKDKFDGAAEVKVVKEDGIEKPRIVMKNSQFKRHTNADLVYMTPSPDFCESDPLRGILGTKGRQCTLAPNAIDDCSLLCCGRGYEKKVQIVEEKCNCKFIYCCEVRCEPCQKRIEKYLCL