culC

Cullin-3

769 amino acids

Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity).

Belongs to the cullin family.

88.886 kDa

MMAKPNGKIQFKNLQSHGVLADPDFPKRTWKLLKTAMRQIHQQNASNLSFEELYRNGYNMVLQKHGDLLYNNLKKMVDKHLKAVAKTVSESIDEKFLLELNSSWINHKTSMLMIRDILMYMDRNYVKQNNLSSVFDLGLYLFRDNVAHCSTIKDRLLNTLLSMVQKEREGEVIDRILIKNIVQMLIDLGVNSKNVYIEDFEKPLLLKTSSHYQAQSQTLIQTCSCPDYMKKVEICLKEELERVSHYLDSSSEPKLKEVCEKQLISNHMRTLIDMENSGLISMLKDDKIEDLKRMYNLFSRVSDGLNLMKDVISSYVKEIGRGIVMDEEKTKESGTYFQSLLDLKDKYDNLLQNALYNDKQFIHSIQQAFEYFINLNPKSPEYISLFIDEKLKKGLKGVSEEEVDIILDKILMLFRLIQEKDVFEKYYKQHLAKRLLLGRSISDDAERNMIAKLKTECGYQFTSKLEGMFTDMRLSQDTMSGFKTYIQNLKKALPIDLNVHVLTTGFWPTQNTANCNLPREILLCCEAFKSYYLSNHNGRLLLWQTNMGTAEIKANFPSKSHELQVSSYQMVILLLFNDQSKLTFKEIADQTGIPTIDLKRNLLALTNPKNKILDRELPSTTSSTTTTTTTATSSSTSTSPSSSSSSISTPTPSKSIDESDVFAFNTKFKSKLFRVKVMAVVQKETPVEEKETRDKVDEDRKHQIEASIVRIMKARKTLEHSNLVSEVIKQLQSRFVPNPVIVKKRIESLIEREYLERSKQDRKIYNYMA