ctxA

Cortexillin-1

444 amino acids

Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1.

Belongs to the cortexillin family.

50.505 kDa

MAGKDWEIVQEKAFTAWVNSVLDKRGEKISDVGKDLSDGVKLIFFLELISSKKFNKKYDFEPKARINMIQNVALALKFLDEELKIKVQGIGSEDFVDNNKKMILGFLWTLYRKYRIAVISEGDKSSEEGLLLWCKNTTTGYDGVNITSFTKSFRDGLAFLALSHKFEPESFKFQEFEAMDPIARLNAAFDFAEKGLGVPKLLEAEEVMRGTTDERSLVLYTSLFFHAYRAKEEKARLESSKNEMANRLAGLENSLESEKVSREQLIKQKDQLNSLLASLESEGAEREKRLRELEAKLDETLKNLELEKLARMELEARLAKTEKDRAILELKLAEAIDEKSKLEQQIEATRIRGAAEAQGLGLLRKNLDTHVHDLLKWQKLTMENSSSSSIDDQIIVEVSGLPFGEQVKHLATKLEAENLAIMKLLNQKEDDLKAQKLKSSKSKK

ctxA

Cortexillin-1

440 amino acids

Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis (By similarity).

Belongs to the cortexillin family.

50.186 kDa

MAGKDWEIVQEKAFTAWVNSVLDKRGEKISDVAKDLSDGVKLIFFLELISGKKFNKKFDYEPKARINMIQNLALALHFLEDELKIKVQGIGAEDFVDNNKKMILGFLWTLYRKYRIAVISEGDKSSEEGLLLWCKNTTTGYNGVNVTSFTKTFRDGLAYLALAHKFDQSQFNFADYEKLDPIARLNAAFEYAEKGLGVPKLLEAEEVMRGTTDERSLVLYTSLFFHAYRAKEEKERLEASKSDLASKLAGLQNSLESEKLSREQLIKQKDELKSLLASLEGEAAEREKFLRELEAKLEEILKNLELERLARMELESRLSKMEKDKAILELKLAEAQDEKARLEAQIEADRIRSAAEAQSLGLLRKHLDQHVQDLIKWQKLSIENSSSTFDDQIIEEVSGLPFGEQVKHLATKLEDENKAIQKLLLSKEDDLKTAKKKAGK

ctxA

Cholera enterotoxin subunit A

258 amino acids

The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring.

Belongs to the enterotoxin A family.

29.336 kDa

MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL